Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2)

By Stephen D. Bentley, K. Chater, A. Cerdeño-Tárraga, G. Challis, N. Thomson, K. James, D. Harris, M. Quail, H. Kieser, D. Harper and 33 more. Nature, 2002

3,106 citations recorded by the source corpus.

Subfields: Microbiology, Molecular Biology, Pharmacology

View Paper: https://www.semanticscholar.org/paper/7fc9cb7dea2e7185d03421a1ff5492d36a2a751b

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Microbiology

1. Gerard D. Wright
2. Nadine Ziemert

In Molecular Biology

1. Rasmus Agren
2. Jens Nielsen
3. John S. Mattick
4. U. Hentschel
5. Eric E. Allen
6. Gerard D. Wright
7. Larry J Croft
8. Jonathan H. Badger

In Pharmacology

1. U. Hentschel
2. Gerard D. Wright
3. P. Jensen
4. Nadine Ziemert
5. A. Harvey

Citations in the corpus

• A Patchwork of Streptomyces Species Isolated from Potato Common Scab Lesions in North America (2009, neutral): “…gene repeat and there are examples of sequence polymorphisms among the rDNA gene copies in a few bacterial species (Klappenbach et al. 2001), but this is infrequent and was not the case for the three published Streptomyces genomes (Bentley et al. 2002; Ikeda et al. 2003; Ohnishi et al. 2008).”
• The Natural Product Domain Seeker NaPDoS: A Phylogeny Based Bioinformatic Tool to Classify Secondary Metabolite Gene Diversity (2012, background): “Genome sequencing has revealed that the secondary metabolite potential of even well studied bacteria has been severely underestimated”
• Biotechnology and molecular biology of the α-glucosidase inhibitor acarbose (2004, background): “However, related gene sets do not occur in all strains; e.g. they are absent from the full-length genomes of S. coelicolor A3(2) and S. avermitilis (Piepersberg 2001; Bentley et al. 2002; Ikeda et al. 2003).”
• Is prokaryotic complexity limited by accelerated growth inregulatory overhead? (2003, background): “In agreement with this general prediction, it has been shown that regulatory gene number in prokaryotic genomes grows disproportionally fast [ 2-5 ].”
• Increasing biological complexity is positively correlated with the relative genome-wide expansion of non-protein-coding DNA sequences (2003, neutral): “8 2618 1669695 [72] Coxiella burnetii 0.11 2094 1995275 [73] Chromobacterium violaceum 0.11 4431 4751080 [74] Pasteurella multocida 0.1106 2014 2257487 [75] Streptomyces coelicolor 0.111 7825 8670000 [76] Chlorobium tepidum TLS 0.111 2288 2154946 [77] Prochlorococcus marinus 0.115 1884 1751080 [78] ”