Mechanisms and functions of eph and ephrin signalling

By K. Kullander, R. Klein. Nature reviews. Molecular cell biology, 2002

1,242 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Molecular Biology, Toxicology

View Paper: https://www.semanticscholar.org/paper/6e114df6488944abe42644bb967332b0fc53d6d8

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In Cellular and Molecular Neuroscience

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E. Pasquale

Citations in the corpus

The PROSITE database (2005, background): “80 ScanProsite output for the human ephrin B4 receptor, which is a functional kinase receptor (5), and its paralogue the ephrin B6 receptor, which is known to have an inactive kinase domain (6).”
Cell adhesion molecules: signalling functions at the synapse (2007, background): “EphBs have a number of protein domains — including a PDZ binding domain, a kinase domain and juxtamembrane tyrosines — that mediate their ability to induce signalling in a number of downstream pathways, such as activation of non-receptor tyrosine kinases and activation of GTPases through particular ”
Osteoblast-Osteoclast Communication and Bone Homeostasis (2020, background): “The Ephrin B family consists of transmembrane proteins with cytoplasmic domains and its interaction with EPHBexpressing cells mediates bidirectional signal transduction [29].”
Central Sensitization: A Generator of Pain Hypersensitivity by Central Neural Plasticity (2009, neutral): “whereas EphrinB is anchored to the presynaptic membrane.(156) The kinase activity of EphBR is not required for the initial clustering of NMDAR at the synapse but is essential for their maintenance.”
Bidirectional ephrinB2-EphB4 signaling controls bone homeostasis. (2006, background): “The interaction between ephrins and Ephs has been extensively investigated in neural development, angiogenesis, skeletal patterning, and other contexts (Compagni et al., 2003; Davy et al., 2004; Himanen and Nikolov, 2003; Kullander and Klein, 2002; Murai and Pasquale, 2003; Palmer and Klein, 2003).”
Developmental cell biology: Eph receptor signalling casts a wide net on cell behaviour (2005, background): “The ensuing signals propagate bidirectionally into both the Eph-receptor-expressing cells (in a process known as forward signalling) and the ephrin-expressing cells (reverse signalling”
Class 3 semaphorins control vascular morphogenesis by inhibiting integrin function (2003, background): “All the vascular defects that we observed in Sema3a -/- embryos phenocopy in part the mutation in ephrin-B2, EphB4 and EphB2/EphB”