The human serotonin transporter gene linked polymorphism (5-HTTLPR) shows ten novel allelic variants

By Masayuki Nakamura, S. Ueno, A. Sano, Hirotaka Tanabe. Molecular Psychiatry, 2000

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Gene–Environment Interactions (2002, background): “…for both the serotonin transporter gene (SERT) and the dopamine transporter gene (DAT), it has recently been reported that they contain many more variants than the simple repeat polymorphisms that, until now, were used in genetic association studies (Nakamura et al., 2000; Miller et al., 2001).”
Serotonin transporter promoter gain-of-function genotypes are linked to obsessive-compulsive disorder. (2006, methodology): “Other novel alleles detected by Nakamura et al.(8) were rare, and we did not observe them, even though we resequenced the HTTLPR region in 106 clinically and ethnically diverse individuals.”
Meta‐analysis of the association between a serotonin transporter promoter polymorphism (5‐HTTLPR) and anxiety‐related personality traits (2004, background): “5-HTTLPR is a repeat polymorphism with two alleles, a 14 repeat (s) and 16 repeat (l), predominant inmost population samples studies to date [Nakamura et al., 2000].”
A susceptibility gene for affective disorders and the response of the human amygdala. (2005, background): “Recent studies have identified another potentially functional variant in the 5-HTTLPR that may further parse the S allele effect.(27,28) This is a minor additional genetic effect, however, that suggests some further refinement of the physiologic response based on 5-HTTLPR genotype may be possible.”