Fibrotic disease and the TH1/TH2 paradigm

By TA Wynn. Nature reviews. Immunology, 2004

1,462 citations recorded by the source corpus.

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

Protective immune mechanisms in helminth infection (2007, background): “However, tissue fibrosis, which is largely stimulated by the cytokine IL-13, can also become pathological and therefore represents a potential downside of the ongoing T H 2-type response to chronic infection (reviewed in Ref”
Liver Fibrosis: Mechanistic Concepts and Therapeutic Perspectives (2020, background): “Organ fibrosis characterizes disease progression in chronic inflammatory diseases and contributes to 45% of all-cause mortality world-wide [2].”
Integrating mechanisms of pulmonary fibrosis (2011, background): “There is a great deal of evidence that CD4+ Th1 and Th2 cells play important roles during the inflammatory/maintenance phase of pulmonary fibrosis (Wynn, 2004).”
Intratumor T helper type 2 cell infiltrate correlates with cancer-associated fibroblast thymic stromal lymphopoietin production and reduced survival in pancreatic cancer (2011, background): “…to favor, in the draining LNs, differentiation of tumor-specific Th2 cells, which then home to the tumor and possibly contribute to disease progression by interacting with other immune and nonimmune cells (Joyce and Pollard, 2009) and, through Th2 cytokines secretion, to fibrosis (Wynn, 2004).”