Intratumor T helper type 2 cell infiltrate correlates with cancer-associated fibroblast thymic stromal lymphopoietin production and reduced survival in pancreatic cancer

By L. De Monte, M. Reni, E. Tassi, Daniela Clavenna, I. Papa, H. Recalde, M. Braga, V. Di Carlo, C. Doglioni, M. Protti. Journal of Experimental Medicine, 2011

657 citations recorded by the source corpus.

Expression of TSLP in pancreatic cancer correlates with Th2 deviation of antitumor immunity that is associated with decrease of patient survival.

Subfields: Immunology, Oncology, Psychiatry and Mental health

View Paper: https://www.semanticscholar.org/paper/66353a1a0f9a11ed8ce10c6d8dc3276703461304

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Citations in the corpus

Immune cell infiltration as an indicator of the immune microenvironment of pancreatic cancer (2013, result): “It was also reported that De Monte et al (2011) found that Th2 rather than Th1 cells predominantly infiltrated in PDC, and that the ratio of tumour-infiltrating Th2/Th1 cells was independently predictive of patient survival.”
Comprehensive and Integrated Genomic Characterization of Adult Soft Tissue Sarcomas. (2017, positive): “Meth2 also had higher inferred content of Th2 cells (Figure S5B), a finding linked to poor outcomes in other cancers (De Monte et al., 2011).”
The Pancreatic Cancer Microbiome Promotes Oncogenesis by Induction of Innate and Adaptive Immune Suppression (2018, positive): “Accordingly, intratumoral CD4+ TH2 cell infiltrates correlate with reduced survival in human PDA (20, 21).”
Crosstalk between cancer-associated fibroblasts and immune cells in the tumor microenvironment: new findings and future perspectives (2021, background): “[218] found that thymic stromal lymphopoietin (TSLP) produced by activated CAFs in pancreatic cancer functions to promote Th2 polarization.”
Immunological Effects of Conventional Chemotherapy and Targeted Anticancer Agents. (2015, background): “…al., 2013 TH1 cells TBX21 + pancreatic carcinoma Adjuvant chemoradiation increased intratumoral TH2/TH1 cell ratio correlated with shortened OS De Monte et al., 2011 TH2 cells GATA3 + TILs CD3+ breast carcinoma neoadjuvant chemotherapy increased amounts of TILs predicted pCR Denkert et al.,…”
Low-dose irradiation programs macrophage differentiation to an iNOS⁺/M1 phenotype that orchestrates effective T cell immunotherapy. (2013, methodology): “Increased intraepithelial T cell infiltrates are correlated with improved survival in patients with pancreatic cancer (De Monte et al., 2011).”
Cancer immunotherapy via dendritic cells (2012, neutral): “A similar pathway operates in pancreatic cancer [88].”
Cancer-related inflammation: common themes and therapeutic opportunities. (2012, background): “[68] hypothesized that umor-resident dendritic cells, conditioned by local factors, may be ble to favor differentiation of tumor-specific Th2 cells in the drainng lymph nodes.”