A role for adult TLX-positive neural stem cells in learning and behaviour

By Chun-li Zhang, Yuhua Zou, Weimin He, Fred H. Gage, R. Evans. 2008

545 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Cognitive Neuroscience, Developmental Neuroscience

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Citations in the corpus

New neurons and new memories: how does adult hippocampal neurogenesis affect learning and memory? (2010, positive): “Similar task-dependent involvement of hippocampal neurogenesis has been observed in other studies in both rats and mic”
Substrate modulus directs neural stem cell behavior. (2008, background): “Adult neural stem cells (aNSCs) have the capacity to differentiate into the three major cell types of the adult nervous system (24), are involved in new memory formation (22,25), respond to neural injury (22), and represent an important potential resource for a wide range of biomedical and neurorege”
Effect of ablated hippocampal neurogenesis on the formation and extinction of contextual fear memory (2009, background): “found no effect of the depletion of neurogenesis on contextual fear conditioning (Table 1) [9].”
Dentate gyrus-specific knockdown of adult neurogenesis impairs spatial and object recognition memory in adult rats. (2009, background): “reported to be intact after blocking hippocampal neurogenesis (Dupret et al. 2008; Zhang et al. 2008).”
Adult neurogenesis modulates the hippocampus-dependent period of associative fear memory. (2009, background): “…focused on the functional roles played by neurogenesis in memory acquisition and in the early period of memory formation (1–3 day memory, recent memory) (Dupret et al., 2008; Imayoshi et al., 2008; Saxe et al., 2006; Shors et al., 2001; Winocur et al., 2006; Zhang et al., 2008; Zhao et al., 2008).”
Development of neural stem cell in the adult brain. (2008, methodology): “Genetic manipulation of adult NSCs using these approaches has further revealed underlying molecular mechanisms [17 ,18 ,19 ] and physiological functions of adult neurogenesis [20] in vivo.”
GABAergic Interneuron Dysfunction Impairs Hippocampal Neurogenesis in Adult Apolipoprotein E4 Knock-in Mice (2009, background): “A recent gene expression microarray analysis also showed expression of apoE in NSCs in mouse brains (Zhang et al., 2008).”
Mechanisms and functional implications of adult neurogenesis. (2008, unknown): “Similarly, no defect in contextural fear conditioning was detected in tlx conditional knockout mice, in which hippocampal neurogenesis was greatly reduced (Zhang et al., 2008).”
Brain-derived Neurotrophic Factor Promotes Differentiation and Maturation of Adult-born Neurons Through GABAergic Transmission (2012, background): “Much work has been dedicated to understanding the role of adult-born neurons in hippocampal function, with recent studies showing that specific suppression or depletion of dentate gyrus progenitor cells led to deficits in fine-tuned spatial discrimination, but not other hippocampal-dependent tasks (”
Effects of adult-generated granule cells on coordinated network activity in the dentate gyrus (2010, background): “…shown that neurogenesis may support hippocampal-dependent behaviors such as contextual fear conditioning (Saxe et al., 2006; Deng et al., 2009), specific Morris water maze paradigms (Snyder et al., 2005; Zhang et al., 2008; Deng et al., 2009), and spatial pattern separation (Clelland et al., 2009).”
Early age-related changes in adult hippocampal neurogenesis in C57 mice. (2010, background): “Studies of behavior after the ablation of AhN have found effects on specific aspects of hippocampus-dependent tasks (Seigers et al., 2008; Zhang et al., 2008), which supports the suggested involvement of AhN in hippocampal function based on correlated changes of AhN and behavior after indirect…”