Thymic selection threshold defined by compartmentalization of Ras/MAPK signalling

By M. Daniels, E. Teixeiro, J. Gill, B. Hausmann, D. Roubaty, K. Holmberg, G. Werlen, G. Holländer, N. Gascoigne, E. Palmer. Nature, 2006

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Subfields: Immunology

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IL-2 modulates the TCR signaling threshold for CD8 but not CD4 T cell proliferation on a single cell level (2017, methodology): “We introduced the Nur77eGFP reporter onto the OVA-specific OTI TCR Tg model, and took advantage of a well-characterized set of OVA-derived altered peptide ligands with varying affinity for this TCR (10, 13).”
T cell receptor signal strength in Treg and iNKT cell development demonstrated by a novel fluorescent reporter mouse (2011, methodology): “We used Kb/OVA-specific OT-I TCR transgenic mice, for which many variant peptide ligands have been characterized (Hogquist et al., 1994; Daniels et al., 2006).”
Ion Channels in Innate and Adaptive Immunity (2015, background): “In vitro, negative selection of T cells induced by high-affinity peptide ligands was associated with strong Ca2+ influx, whereas positive selection by weak peptide-MHCTCR interactions induced only moderate Ca2+ influx (120, 121).”
CD4+T Cells: Differentiation and Functions (2012, background): “Blymphocytes mature in the bone marrow itself, while the T-lymphocytes require the thymus to mature, before being deployed to the peripheral lymphoid organs for further antigen-mediated differentiation.”