Adaptive regulation of neuronal excitability by a voltage- independent potassium conductance

By S. Brickley, V. Revilla, S. Cull-Candy, W. Wisden, M. Farrant. Nature, 2001

605 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Cognitive Neuroscience, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/7f2c52463c47499a4dc0f33a2e0a8d6d7b0c0dc1

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Citations in the corpus

Extrasynaptic GABAA receptors: Their function in the CNS and implications for disease (2012, background): “a6bd subunit-containing GABAARs mediate a tonic form of inhibition both in vitro (Brickley et al., 2001; Hamann et al., 2002) and in vivo (Chadderton et al.”
Reduced Inhibition and Sensitivity to Neurosteroids in Hippocampus of Mice Lacking the GABAA Receptor δ Subunit (2003, background): “In cerebellar granule cells, concurrent loss of 6 and subunits in 6 knockout mice results in a complete loss of tonic GABAergic inhibition mediated via extrasynaptic GABAARs (Brickley et al. 2001).”
Raising cytosolic Cl− in cerebellar granule cells affects their excitability and vestibulo‐ocular learning (2012, neutral): “In contrast to PCs, GCs express highly sensitive and non-inactivating a 6 d -containing GABA A Rs (Laurie et al , 1992; Saxena and Macdonald, 1996; Brickley et al , 2001; Rossi et al , 2003; Hadley and Amin, 2007) and display tonic inhibition by ambient GABA (Brickley et al , 1996) which may come…”
Cell Types, Network Homeostasis, and Pathological Compensation from a Biologically Plausible Ion Channel Expression Model (2014, positive): “Experiments show that neurons use activity-dependent feedback to regulate membrane conductances and receptors (Amendola et al., 2012; Baines et al., 2001; Brickley et al., 2001; Desai et al., 1999; Golowasch et al., 1999a; Mee et al., 2004; O’Leary et al., 2010; Neuron.”
GABA Transporter Deficiency Causes Tremor, Ataxia, Nervousness, and Increased GABA-Induced Tonic Conductance in Cerebellum (2005, background): “This resembles the 98 20 pS/pF GGABA recorded previously in the C57BL/6 strain (Brickley et al., 2001).”
Cell Types, Network Homeostasis, and Pathological Compensation from a Biologically Plausible Ion Channel Expression Model. (2015, positive): “Experiments show that neurons use activity-dependent feedback to regulate membrane conductances and receptors (Amendola et al., 2012; Baines et al., 2001; Brickley et al., 2001; Desai et al., 1999; Golowasch et al., 1999a; Mee et al., 2004; O'Leary et al., 2010; Turrigiano et al., 1994, 1995).”
Neuronal homeostasis: time for a change? (2011, background): “…lesion (Turrigiano et al. 1994) and that mammalian central neurones modify their intrinsic membrane properties in a way that counters the effects of imposed changes in excitatory drive (Desai et al. 1999; Brickley et al. 2001; van Welie et al. 2006; Maffei & Turrigiano, 2008; O’Leary et al. 2010).”
Network Structure within the Cerebellar Input Layer Enables Lossless Sparse Encoding (2014, background): “The importance of a high GC spike threshold to cerebellar function is reinforced by the finding that when tonic inhibition was eliminated in GABAAa6 knockoutmice, two-pore K+ channels were upregulated, thereby maintaining threshold at a high level (Brickley et al., 2001).”
GABAA receptor changes in δ subunit‐deficient mice: Altered expression of α4 and γ2 subunits in the forebrain (2002, background): “However, an increase in a voltageindependent K leak conductance occurs in the cerebellum of 6–/– mice, and this appears to be a form of homeostatic plasticity that helps to maintain normal granule cell excitability (Brickley et al., 2001).”
Properties of Somatosensory Synaptic Integration in Cerebellar Granule Cells In Vivo (2006, result): “In line with previous in vitro studies (Silver et al., 1992, 1996; D’Angelo et al., 1995; Brickley et al., 2001), we found that the peak amplitudes of unitary mossy fiber EPSPs evoked by electrical stimulation had a low variability (Fig.”