GABAA receptor changes in δ subunit‐deficient mice: Altered expression of α4 and γ2 subunits in the forebrain

By Zechun Peng, B. Hauer, R. Mihalek, G. Homanics, W. Sieghart, Richard W. Olsen, C. Houser. 2002

236 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/2a508b57c36f664099701ef2490e1201ad0b03c0

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In Cellular and Molecular Neuroscience

In Molecular Biology

Citations in the corpus

Reduced Inhibition and Sensitivity to Neurosteroids in Hippocampus of Mice Lacking the GABAA Receptor δ Subunit (2003, unknown): “Recent studies indicate that the distribution of various GABA A R subunits in the mouse brain closely resembles that of the rat (Tretter et al. 2001; Peng et al. 2002).”
The δ Subunit of γ-Aminobutyric Acid Type A Receptors Does Not Confer Sensitivity to Low Concentrations of Ethanol (2006, unknown): “-Deficient mice (Mihalek et al., 1999) showed decreased 4 subunit expression in forebrain, whereas 2S subunit levels were increased (Peng et al., 2002).”
GABAA receptor trafficking and its role in the dynamic modulation of neuronal inhibition (2008, background): “Similarly, there is a decrease in the levels of the α4 subunit in the forebrain of δ-subunit-deficient mice, whereas the levels of the α1 subunit remain unchange”
Compensatory alteration of inhibitory synaptic circuits in cerebellum and thalamus of γ‐aminobutyric acid type A receptor α1 subunit knockout mice (2006, background): “The 4 subunit overlaps with the 1 subunit in several major relay nuclei (Peng et al., 2002).”
Trace fear conditioning is enhanced in mice lacking the δ subunit of the GABAA receptor (2005, background): “It should be noted that the subunit is conspicuously absent from several brain regions known to be essential for fear conditioning (e.g., amygdala, periaqueductal gray) (Fendt and Fanselow 1999; Peng et al. 2002).”
International Union of Pharmacology. LXX. Subtypes of γ-Aminobutyric AcidA Receptors: Classification on the Basis of Subunit Composition, Pharmacology, and Function. Update (2008, background): “The (cid:8) subunit seems to have a perisynaptic/extra-synaptic localization (Nusser et al., 1998; Peng et al., 2002; Wei et al., 2003).”
Tonically active GABA A receptors: modulating gain and maintaining the tone. (2004, background): “Hippocampal interneurons have been reported to express d subunits at low level [ 66 ].”