Age‐related differences in the dose–response relationship of muscle protein synthesis to resistance exercise in young and old men

By Vinod Kumar, A. Selby, D. Rankin, Rekha C. Patel, P. Atherton, W. Hildebrandt, JohnL . Williams, Kenneth Smith, O. Seynnes, N. Hiscock and 1 more. Journal of Physiology, 2009

735 citations recorded by the source corpus.

Subfields: Cell Biology, Molecular Biology, Orthopedics and Sports Medicine

View Paper: https://www.semanticscholar.org/paper/7f0413203071025cc635a35513d42c8715a21836

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In Cell Biology

1. J. Zierath
2. Marco Narici

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1. J. Zierath
2. B. Egan

In Orthopedics and Sports Medicine

1. J. Zierath

Citations in the corpus

• The age-related loss of skeletal muscle mass and function: Measurement and physiology of muscle fibre atrophy and muscle fibre loss in humans (2018, background): “, 2005) and exercise (Kumar et al., 2009) are blunted compared to younger people.”
• Resistance exercise load does not determine training-mediated hypertrophic gains in young men. (2012, background): “As proof-of-principle, we recently tested this idea and demonstrated (9) that a single bout of resistance exercise performed at 30% of 1RM to the point of momentary muscle fatigue (failure) was equally as effective in stimulating myofibrillar protein synthesis rates (MPS) as loads lifted at 90% of 1”
• Sarcopenia, Dynapenia, and the Impact of Advancing Age on Human Skeletal Muscle Size and Strength; a Quantitative Review (2012, background): “However in young men this rate more than doubles upon either feeding or exercise but in old men these responses are blunted (Cuthbertson et al., 2005; Kumar et al., 2009).”
• Protein supplementation augments the adaptive response of skeletal muscle to resistance-type exercise training: a meta-analysis. (2012, background): “Because the muscle protein synthetic response to nutritional (42, 43) and/or exercise (44, 45) stimuli has been reported to be blunted in senescent muscle, it is of even greater importance to define dietary interventions that can augment the benefits of exercise training in the elderly population.”
• Skeletal muscle performance and ageing (2017, neutral): “addition, the protein synthetic signalling proteins p70 ribosomal S6 kinase and eukaryotic initiation factor 4E binding protein 1 were 30–40% lower phosphorylated in older adults vastus lateralis muscle.(54) In addition to the lower postprandial skeletal muscle response to anabolic stimuli, some”
• Exercise metabolism and the molecular regulation of skeletal muscle adaptation. (2013, background): “, 2008), or in elderly individuals reported to demonstrate ‘‘anabolic resistance’’ with respect to exerciseinduced MPS (Kumar et al., 2009).”