Consumption of ultra-processed foods and cancer risk: results from NutriNet-Santé prospective cohort
By Thibault Fiolet, B. Srour, L. Sellem, E. Kesse‐Guyot, B. Allès, C. Méjean, M. Deschasaux, P. Fassier, P. Latino-Martel, M. Beslay and 5 more. British medical journal, 2018
882 citations recorded by the source corpus.
Abstract Objective To assess the prospective associations between consumption of ultra-processed food and risk of cancer. Design Population based cohort study. Setting and participants 104 980 participants aged at least 18 years (median age 42.8 years) from the French NutriNet-Santé cohort (2009-17). Dietary intakes were collected using repeated 24 hour dietary records, designed to register participants’ usual consumption for 3300 different food items. These were categorised according to their degree of processing by the NOVA classification. Main outcome measures Associations between ultra-processed food intake and risk of overall, breast, prostate, and colorectal cancer assessed by multivariable Cox proportional hazard models adjusted for known risk factors. Results Ultra-processed food intake was associated with higher overall cancer risk (n=2228 cases; hazard ratio for a 10% increment in the proportion of ultra-processed food in the diet 1.12 (95% confidence interval 1.06 to 1.18); P for trend<0.001) and breast cancer risk (n=739 cases; hazard ratio 1.11 (1.02 to 1.22); P for trend=0.02). These results remained statistically significant after adjustment for several markers of the nutritional quality of the diet (lipid, sodium, and carbohydrate intakes and/or a Western pattern derived by principal component analysis). Conclusions In this large prospective study, a 10% increase in the proportion of ultra-processed foods in the diet was associated with a significant increase of greater than 10% in risks of overall and breast cancer. Further studies are needed to better understand the relative effect of the various dimensions of processing (nutritional composition, food additives, contact materials, and neoformed contaminants) in these associations. Study registration Clinicaltrials.gov NCT03335644.
Subfields: Genetics, Nutrition and Dietetics, Public Health, Environmental and Occupational Health
View Paper: https://www.semanticscholar.org/paper/7e5aa1197175957af5cc86522001a1870499cfde
How researchers see this paper
The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.
In Nutrition and Dietetics
In Public Health, Environmental and Occupational Health
Citations in the corpus
- Consumption of ultra-processed foods and health status: a systematic review and meta-analysis (2020, background): “In addition, results from a large French prospective cohort study, the NutriNet-Santé study, found that high UPF consumption led to a significant increase in the risk of CVD (13) , diabetes (14) , depressive symptoms (15) and cancer (16) .”
- Ultra-processed food intake and risk of cardiovascular disease: prospective cohort study (NutriNet-Santé) (2019, background): “37 40-43 It is therefore important to inform consumers about these associations and to implement actions targeting product reformulation (eg, improving nutritional quality and reducing the use of unnecessary additives), taxation, and communication to limit the proportion of ultra-processed foods in…”
- Ultra-Processed Foods and Health Outcomes: A Narrative Review (2020, methodology): “[84] found a higher incident rate of cancer with UPF exposure.”
- Triple-Negative Breast Cancer: A Brief Review About Epidemiology, Risk Factors, Signaling Pathways, Treatment and Role of Artificial Intelligence (2022, background): “The obesity-causing ultra-processed diet plans that are enriched in elements such as sugar, sodium, and fats are thought to be carcinogenic and increase the risk by 11% (Fiolet et al., 2018).”
- Breast Cancer—Epidemiology, Risk Factors, Classification, Prognostic Markers, and Current Treatment Strategies—An Updated Review (2021, background): “Ultra-processed food is rich in sodium, fat, and sugar which subsequently predisposes to obesity recognized as another factor of breast cancer risk [118].”