The role of short-chain fatty acids in microbiota–gut–brain communication
By B. Dalile, L. Van Oudenhove, Bram Vervliet, K. Verbeke. Nature reviews: Gastroenterology & hepatology, 2019
2,796 citations recorded by the source corpus.
Subfields: Biological Psychiatry, Gastroenterology, Molecular Biology
View Paper: https://www.semanticscholar.org/paper/7e4ed16f3ce55dfd717da71ac0dce3281339eda3
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In Biological Psychiatry
In Gastroenterology
In Molecular Biology
- M. Collado
- Antonio Gasbarrini
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- Ana Nogal
- Paulina Markowiak-Kopeć
- M. De Angelis
- Ygor P. Silva
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Citations in the corpus
- The Role of Short-Chain Fatty Acids From Gut Microbiota in Gut-Brain Communication (2020, background): “In addition to the longknown role of the colon in energy supply and trophic factors (22), as well as the regulation of T regulatory (Treg) cell colonies (23, 24), growing evidence supports the idea that SCFAs also exert crucial physiological effects on several organs, including the brain (17, 20, 21”
- Gut Microbiota and Short Chain Fatty Acids: Implications in Glucose Homeostasis (2022, background): “Bacteria species intake lactate and succinate and convert them into propionates [37].”
- Short-Chain Fatty-Acid-Producing Bacteria: Key Components of the Human Gut Microbiota (2023, background): “Additionally, high concentrations of SCFAs seem to be related to the major expression of neurotrophic factors [41]; SCFAs may induce the expression of tryptophan 5-hydroxylase 1, an enzyme involved in serotonin biosynthesis [42], and there is also evidence that they may positively affect the brain b”
- The Effect of Probiotics on the Production of Short-Chain Fatty Acids by Human Intestinal Microbiome (2020, background): “SCFAs are speculated to have a mediational role in the microbiota–gut–brain axis crosstalk [56].”
- The role of short-chain fatty acids in the interplay between gut microbiota and diet in cardio-metabolic health (2021, background): “FFAR3, FFAR2, and GPR109a are expressed by different organs and cells: small intestine, colon, liver, spleen, heart, skeletal muscle, neurons, immune cells, and adipose tissues.(98) Additionally, depending on the length of their aliphatic tails, the receptors present different affinities for SCFAs.”
- Short-chain fatty acids: linking diet, the microbiome and immunity (2024, positive): “SCFAs are key mediators of the microbiota–gut–brain crosstalk and are involved in the modulation of microglia , production of neurotrophic factors and maintenance of the blood–brain barrier integrity, as well as in neurogenesis 139 .”
- SCFA: mechanisms and functional importance in the gut (2020, background): “The transporters MCT1, SMCT1 and SLC26A3 show affinities for all three major SCFA while the other ones are more selective, e.g. SMCT2 Fig.”