Alzheimer' Disease as a Disconnection Syndrome?

By Xavier Delbeuck, Martial van der Linden, Fabienne Collette. Neuropsychology Review, 2003

692 citations recorded by the source corpus.

Subfields: Cognitive Neuroscience, Psychiatry and Mental health, Radiology, Nuclear Medicine and Imaging

View Paper: https://www.semanticscholar.org/paper/7d88a684ced01532f8c05e04d907c3cdc6e9900d

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cognitive Neuroscience

1. Yong He
2. Olaf Sporns
3. Alan C. Evans
4. Vinod Menon
5. E. Bullmore
6. Yufeng Zang
7. Cornelis J. Stam
8. Xi-Nian Zuo

In Psychiatry and Mental health

1. Liang Wang
2. Yufeng Zang
3. Philip Scheltens
4. Vinod Menon
5. Jieping Ye
6. Alan C. Evans
7. Meng Liang
8. Kun Wang

In Radiology, Nuclear Medicine and Imaging

1. Yong He
2. Alan C. Evans
3. Olaf Sporns
4. Yufeng Zang
5. Vinod Menon
6. Cornelis J. Stam
7. Michael D. Greicius
8. Zhang John Chen

Citations in the corpus

• Learning brain connectivity of Alzheimer’s disease by sparse inverse covariance estimation (2010, background): “It has been speculated by a number studies and accepted more widely recently that higher cognition results from different brain regions interacting with each other, rather than individual regions working independently (Horwitz, 2003; Delbeuck et al., 2003).”
• Nonlinear dynamical analysis of EEG and MEG: review of an emerging field. (2005, background): “Consequently one might expect that brain dynamics in such disorders, in particular Alzheimer’s disease, is characterized by a lower level of synchronization of ongoing brain activity, and that this loss of functional connectivity interferes with normal information processing (Delbeuck et al., 2003).”
• Structural Insights into Aberrant Topological Patterns of Large-Scale Cortical Networks in Alzheimer's Disease (2008, background): “Current theories of AD have posited that the decline arises from alterations in functional integration of distributed brain systems or from structural disconnection between regions because of white matter damage (for review, see Delbeuck et al., 2003).”
• Graph theoretical analysis of magnetoencephalographic functional connectivity in Alzheimer's disease. (2009, neutral): “It has even been suggested that Alzheimer’s disease can be viewed as a disconnec- tion syndrome (Delbeuck et al., 2003).”
• Networks of anatomical covariance (2013, background): “AD is a salient example of a “disconnection syndrome” (Buckner et al., 2009; Delbeuck et al., 2003), wherein disease propagates in a atrophy patterns (Zhou et al., 2012): Epicenters: ROIs whose healthy intrinsic conneccenters shown on images.”
• Network Analysis of Intrinsic Functional Brain Connectivity in Alzheimer's Disease (2008, background): “reported reduced resting-state functional connectivity in the default-mode network of MCI patients. Although evidence is accumulating that AD disrupts functional connections between brain regions”
• Act-In: An integrated view of memory mechanisms (2014, background): “This would result in a cognitive deficit that is more severe in situations requiring a transfer of information between different brain regions (e.g., Delbeuck et al., 2003; Stam, Jones, Nolte, Breakspear, & Scheltens, 2007; Vallet, Hudon, Simard, & Versace, 2013).”
• Loss of ‘Small-World’ Networks in Alzheimer's Disease: Graph Analysis of fMRI Resting-State Functional Connectivity (2010, background): “Alzheimer disease (AD) has been characterized as a disconnection syndrome (”
• Functional neural network analysis in frontotemporal dementia and Alzheimer's disease using EEG and graph theory (2009, result): “The loss of structure as expressed by the lower clustering and path length in the higher frequency bands in AD seems to support the notion of AD as a disconnection syndrome, together with the well known slowing of brain activity and loss of functional connectivity in AD [ 32 ].”
• Changes in hippocampal connectivity in the early stages of Alzheimer's disease: Evidence from resting state fMRI (2006, background): “, 1984, 1986) and raise the possibility that functional interactions between the hippocampus and other related brain regions may be abnormal in the early stages of AD (Delbeuck et al., 2003).”
• Altered functional connectivity in early Alzheimer's disease: A resting‐state fMRI study (2007, background): “There has been much anatomical evidence pointing toward AD as a disconnection syndrome [ Delbeuck et al., 2003 ].”