Diversity of the mammalian sodium/proton exchanger SLC9 gene family

By J. Orlowski, S. Grinstein. Pflügers Archiv, 2004

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Amiloride inhibits macropinocytosis by lowering submembranous pH and preventing Rac1 and Cdc42 signaling (2010, methodology): “Amiloride, a guanidinium-containing pyrazine derivative, has been used extensively as an inhibitor of Na/H exchangers (NHEs; Grinstein et al., 1989; Orlowski and Grinstein, 2004).”
The role of disturbed pH dynamics and the Na+/H+ exchanger in metastasis (2005, background): “The primary extracellular signals and the subsequent signal-transduction systems that regulate NHE1 activity and downstream function are well understood in normal cell”
Alkaline pH homeostasis in bacteria: new insights. (2005, background): “This implies that, as in eukaryotic Na/ H antiporters, there is a pH regulatory site that is distinct from the active site [43,144,152,153].”