Uncoupling to survive? The role of mitochondrial inefficiency in ageing.

By M. Brand. Experimental Gerontology, 2000

811 citations recorded by the source corpus.

Subfields: Molecular Biology, Physiology

View Paper: https://www.semanticscholar.org/paper/7cfb934057f219e58da9c815e49c687cd5f3e305

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Citations in the corpus

Suppression of reactive oxygen species and neurodegeneration by the PGC-1 transcriptional coactivators. (2006, background): “*Contact: bruce_spiegelman@dfci.harvard.edu DOI 10.1016/j.cell.2006.09.024”
Mitochondrial electron transport chain, ROS generation and uncoupling (Review) (2019, background): “Therefore, mild uncoupling is a feedback mechanism adopted by the body to prevent excessive ROS in the mitochondria, which was termed ‘uncoupling to survive’ (187).”
From molecules to living systems: historical and contemporary issues in oxidative stress and antioxidant ecology (2010, background): “Importantly, this uncoupling can result in a positive relationship betweenmetabolic rate and lifespan (‘uncoupling to survive hypothesis’ Brand 2000; Speakman et al. 2002).”
Life history correlates of oxidative damage in a free‐living mammal population (2009, result): “…be noted, however, that such a simple relationship between metabolic rate and ROS production is currently under challenge: mitochondrial uncoupling can lead to associations between metabolism, ROS production and lifespan that are opposite to those predicted above (Brand 2000; Speakman et al .”
Oxidative stress as a mediator of life history trade-offs: mechanisms, measurements and interpretation. (2009, background): “…uncoupling of oxygen consumption and ATP generation, which results in the production of heat, reduces mitochondrial ROS production; the metabolic substrate is also important because the use of fatty acids as a metabolic substrate seems to increase uncoupling (Brand 2000; Hulbert et al. 2007).”
Body size, energy metabolism and lifespan (2005, background): “A model of O (–)(2) generation in the complex III of the electron transport chain.”
The evolutionary ecology of senescence (2008, background): “The production of ROS in the mitochondria can be reduced by altering membrane proton gradients ( Brand 2000; Balaban, Nemoto & Finkel 2005), but this results in reduced efficiency in producing ATP and increased overall energy requirement (Serra et al. 2003; Speakman et al. 2004; Humphries et al. 20”
The sites and topology of mitochondrial superoxide production (2010, background): “This might lower oxidative damage and increase lifespan (Brand, 2000; Skulachev, 1996).”
Life and death: metabolic rate, membrane composition, and life span of animals. (2007, background): “Such uncoupled mitochondrial metabolism has been suggested to result in lower generation of ROS but greater generation of heat (36).”