Human type 1 innate lymphoid cells accumulate in inflamed mucosal tissues

By J. Bernink, C. Peters, M. Munneke, A. Velde, S. Meijer, K. Weijer, H. Hreggvidsdóttir, Sigrid E. M. Heinsbroek, N. Legrand, C. Buskens and 3 more. Nature Immunology, 2013

987 citations recorded by the source corpus.

Subfields: Immunology, Surgery

View Paper: https://www.semanticscholar.org/paper/7cd22add1a8a4877837d46270f958052fa44da71

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Immunology

1. A. Diefenbach
2. Andrew N. J. McKenzie
3. M. Colonna
4. Miriam Merad
5. Yajie Chang
6. Judy H. Cho
7. Hye Young Kim
8. J. D. Di Santo

In Surgery

1. Andrew N. J. McKenzie
2. Yajie Chang
3. Hye Young Kim
4. D. Umetsu
5. Sanhong Yu
6. R. DeKruyff

Citations in the corpus

• Innate lymphoid cells and asthma. (2014, positive): “Type 1 ILCs (ILC1s) are related to NK cells in that they both express T-bet and IFN-g, but ILC1s do not appear to express perforin, granzyme B, or killer-cell immunoglobulin-like receptors and respond primarily to IL-7 rather than IL-15 (Fig 1).(10) Human ILC1s have been shown to expand in the intes”
• Innate and adaptive immunity in inflammatory bowel disease. (2014, background): “[106] observed selective accumulation of CD56-cKit-Nkp44- ILC, which express IFN-gamma and T-bet, in the inflamed intestine of CD patients.”
• Innate Lymphoid Cells: a new paradigm in immunology (2015, background): “In certain tissues, the prompt production of effector cytokines is shared with “innate” T cells, such as mucosa-associated invariant T (MAIT) cells that produce IFN-g, IL-17, and IL-22 (77); invariant NKT (iNKT) cells that produce IFN-g or IL-4 (78); and subsets of gd T cells that produce IFN-g and ”
• Single-Cell Analysis of Crohn’s Disease Lesions Identifies a Pathogenic Cellular Module Associated with Resistance to Anti-TNF Therapy (2019, background): “Because some cells also expressed IL7R, we chose to annotate this cluster as Group 1 ILCs to encompass NK cells, CD127+ ILC1 and potential IFNγ-producing “ex-ILC3s” whose origin remains unclear (Bernink et al., 2013; Simoni and Newell, 2017).”
• Differentiation of type 1 ILCs from a common progenitor to all helper-like innate lymphoid cell lineages. (2014, positive): “as NKp46 and then downregulate RORgt, allowing for phenotypic and functional plasticity (Bernink et al., 2013; Klose et al., 2013; Rankin et al., 2013).”