Dickkopf1 is required for embryonic head induction and limb morphogenesis in the mouse.

By M. Mukhopadhyay, S. Shtrom, Concepción Rodríguez-Esteban, Lan Chen, T. Tsukui, Lauren Gomer, D. Dorward, A. Glinka, A. Grinberg, S. Huang and 3 more. Developmental Cell, 2001

709 citations recorded by the source corpus.

Subfields: Molecular Biology

View Paper: https://www.semanticscholar.org/paper/7cd1804855c2c9962c75b2e2bf3260ae21d5ceaf

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In Molecular Biology

1. Christof Niehrs
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3. Lorenza Ciani
4. P. Salinas
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Citations in the corpus

• Signalling in neural development: WNTS in the vertebrate nervous system: from patterning to neuronal connectivity (2005, background): “Ectopic expression of DKK1 leads to enlargement of the head, whereas loss of DKK1 function induces microcephaly or loss of anterior structure”
• Directed differentiation of telencephalic precursors from embryonic stem cells (2005, background): “This effect of Wnt occurs during relatively late developmental stages, as compared with the effect of Wnt signaling in the inhibition of neural differentiation and forebrain development, which occurs during earlier stage”
• Function and biological roles of the Dickkopf family of Wnt modulators (2006, background): “Consistent with a role in prechordal plate specification, Dkk1 null mutant mice express no or reduced levels of Hesx1 (Mukhopadhyay et al., 2001), as is the case for Xenopus embryos injected with anti-Dkk1 antibody (Dkk1 Ab) (Kazanskaya et al., 2000).”
• Secreted antagonists of the Wnt signalling pathway (2003, background): “Moreover, Xenopusembryos injected with an anti-Dkk-1 antibody (Glinka et al., 1998) and Dkk-1-knockout mice (Mukhopadhyay et al., 2001) lack anterior head structures, indicating that Dkk-1 is essential for head formation.”
• Dorsal-ventral patterning and neural induction in Xenopus embryos. (2004, background): “In the mouse, Dkk-1 homozygous mutants lack CNS structures anterior to the midbrain (Mukhopadhyay et al. 2001), and heterozygotes show strong cooperation with noggin in head formation (del Barco et al. 2003).”
• Secreted and transmembrane wnt inhibitors and activators. (2013, background): “5) the anterior marker Hesx1 fails to be expressed (Mukhopadhyay et al. 2001).”