Phytochemicals from cruciferous plants protect against cancer by modulating carcinogen metabolism.

By P. Talalay, J. Fahey. Journal of NutriLife, 2001

609 citations recorded by the source corpus.

Subfields: Molecular Biology, Organic Chemistry

View Paper: https://www.semanticscholar.org/paper/7cc4e7d08c651851313e146907c0cacfed36da4b

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Molecular Biology

1. Donna D. Zhang
2. J. Cross
3. Shih-Ching Lo
4. D. Templeton
5. Jorge M. Vivanco
6. T. Kensler
7. H. Bais
8. Mark Hannink

In Organic Chemistry

1. Donna D. Zhang

Citations in the corpus

• Mechanistic Studies of the Nrf2-Keap1 Signaling Pathway (2006, background): “now commonly referred to as chemopreventive agents or anti-carcinogens, can lower the risk of cancer in mammals that are exposed to carcinogens (Kensler et al., 2000; Talalay and Fahey, 2001; Wolf, 2001).”
• Bio-protective effects of glucosinolates - a review. (2009, background): “…found to impose significant protection against cancer in animal models induced by a variety of chemical carcinogens (Conaway, Yang, & Chung, 2002; Hecht, 2000; Jiao et al., 1997; Morse et al., 1989 Morse et al., 1991, Stoner et al., 1991; Talalay & Fahey, 2001; Wattenberg, 1977; Yang et al., 2002).”
• Distinct Cysteine Residues in Keap1 Are Required for Keap1-Dependent Ubiquitination of Nrf2 and for Stabilization of Nrf2 by Chemopreventive Agents and Oxidative Stress (2003, background): “There is compelling evidence from epidemiological studies and from laboratory-based experiments that the incidence of cancer can be reduced by dietary consumption of various plantderived chemicals (2, 16, 17, 38, 42).”
• Physiological effects of broccoli consumption (2008, background): “…colleagues have extended Wattenberg’s theory to suggest that, because the phase I detoxification enzyme CYP1A1 is able to bioactivate a number of carcinogens, specifically an increase in phase II detoxification enzymes could be expected to best clear chemical carcinogens (Talalay and Fahey 2001).”
• Keap1 Is a Redox-Regulated Substrate Adaptor Protein for a Cul3-Dependent Ubiquitin Ligase Complex (2004, background): “Indeed, chemical inducers of Nrf2-dependent gene expression are promising cancer-preventive agents (32, 50).”
• Aflatoxin: a 50-year odyssey of mechanistic and translational toxicology. (2011, background): “Many foods have high levels of these enzyme inducers (Fahey and Kensler, 2007; Talalay and Fahey, 2001).”
• Andean root and tuber crops: Underground rainbows (2003, background): “The reported antibiotic, anticancer, and diuretic properties of isothiocyanates support the many uses of mashua in Andean folk medicine (Fahey et al., 1997; Johns et al., 1982; Talalay and Fahey, 2001).”
• Role of secondary metabolites in defense mechanisms of plants (2011, background): “…aglycon rearranges with loss of the sulphate to give pungent and chemically reactive products, including isothiocyanates and nitriles, function in defense as herbivorous toxins and feeding repellent (Renwick, 1992; Grubb and Abel, 2006; Halkier and Gershenzon, 2006; Talalay and Fahey, 2001).”