Both corepressor proteins SMRT and N‐CoR exist in large protein complexes containing HDAC3
By Jiwen Li, Jin Wang, Jianxiang Wang, Z. Nawaz, Johnson M. Liu, J. Qin, J. Wong. EMBO Journal, 2000
670 citations recorded by the source corpus.
Subfields: Genetics, Molecular Biology
View Paper: https://www.semanticscholar.org/paper/7c330ec6b15e98ec7b2b6f97c0b0f1875b6a8b6d
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Citations in the corpus
- The SMRT and N-CoR Corepressors Are Activating Cofactors for Histone Deacetylase 3 (2001, background): “These results are in agreement with previous studies where microinjection of anti-HDAC3 antibodies abrogated N-CoRmediated repression in both Rat1 cells (25) and Xenopus oocytes (34).”
- The Rpd3/Hda1 family of lysine deacetylases: from bacteria and yeast to mice and men (2008, background): “Conversely, HDAC3 was identified through affinity purification of both corepressor”
- Histone Deacetylase Inhibitors as Anticancer Drugs (2017, background): “HDAC complexes can contribute to gene repression through two mechanisms—specific targeting by repressors and the constitutive association with chromatin [24,25].”
- HES and HERP families: Multiple effectors of the notch signaling pathway (2003, background): “However, recent data show that the purified mammalian Sin3 complex does not contain N-CoR (Zhang et al., 1997), nor is Sin3 present in the N-CoR-related SMRT complex (Guenther et al., 2000; Li et al., 2000).”