2 The Pathway and Mechanism of Initiation of Protein Synthesis

By J. Hershey, W. Merrick. 2000

326 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/7ba866445a9f9f20a6c43ee9812c70d5e234068c

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Molecular Biology

Citations in the corpus

Internal ribosome entry sites in eukaryotic mRNA molecules. (2001, methodology): “The 40S subunit carrying the initiator methionine-tRNA and certain eukaryotic initiation factors (eIFs) is thought to scan the mRNA in a 5 to 3 direction until an appropriate start codon is encountered at which stage a 60S subunit joins to form an 80S ribosome that can decode the RNA into protein (K”
Regulation of translation initiation by FRAP/mTOR. (2001, background): “S6Ks phosphorylate the ribosomal protein S6, and possibly the translation initiation factor eIF4B (see below; for review, see Fumagalli and Thomas 2000; Hershey and Merrick 2000).”
Evidence that ternary complex (eIF2-GTP-tRNA(i)(Met))-deficient preinitiation complexes are core constituents of mammalian stress granules. (2002, background): “Eukaryotic translational initiation in vitro (reviewed by Dever, 1999; Pestova and Hellen, 1999; Hershey and Merrick, 2000) begins with the binding of eIF3 to the 40S ribosomal subunit.”
Hierarchical phosphorylation of the translation inhibitor 4E-BP1. (2001, background): “…X is any nucleotide), present at the 5 end of nuclear transcribed mRNAs (for reviews, see Hershey and Merrick 2000; Raught et al. 2000b). eIF4E directs the translation machinery to the 5 end of mRNA via an interaction with the scaffolding protein eIF4G (for review, see Hershey and Merrick 2000).”
The eukaryotic translation initiation factors eIF1 and eIF1A induce an open conformation of the 40S ribosome. (2007, background): “…complex. eIF1 and eIF1A are small proteins (12 and 17 kDa, respectively ) that bind cooperatively to the 40S subunit with high affinity (Maag and Lorsch, 2003), are essential for viability in yeast, and are highly conserved among all eukaryotes (Hershey and Merrick, 2000; Kapp and Lorsch, 2004b).”
Upstream and downstream of mTOR. (2004, background): “As stated above, eIF4B is required for efficient recruitment of ribosomes to mRNA (Hershey and Merrick 2000). eIF4B is an RNA-binding protein that specifically stimulates the ATPase and RNA helicase activities of eIF4A (Rogers et al. 2002). eIF4B is phosphorylated in response to a variety of…”
Regulation of translation via mRNA structure in prokaryotes and eukaryotes. (2005, background): “It is wrong to say that “purines in positions −3 and +4” define an efficient initiation site (Hershey and Merrick, 2000); in fact, G is the only effective base in position +4.”