AML-1 is required for megakaryocytic maturation and lymphocytic differentiation, but not for maintenance of hematopoietic stem cells in adult hematopoiesis

By M. Ichikawa, T. Asai, Toshiki I. Saito, G. Yamamoto, S. Seo, I. Yamazaki, T. Yamagata, K. Mitani, S. Chiba, H. Hirai and 2 more. Nature Medicine, 2004

681 citations recorded by the source corpus.

Subfields: Hematology, Immunology

View Paper: https://www.semanticscholar.org/paper/7b3228d994a0fd91b2ccc29df3dc5e91d0abd885

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Hematology

1. Leonard I. Zon
2. S. Morrison
3. Daniel G. Tenen

In Immunology

1. E. Dzierzak
2. S. Morrison
3. Stuart H. Orkin
4. N. Speck

Citations in the corpus

• Hematopoiesis: an evolving paradigm for stem cell biology. (2008, background): “Similarly, inactivation of Runx1 in adult HSCs does not ablate HSC properties but instead perturbs differentiation of specific lineages (megakaryocytes, lymphocytes) (Ichikawa et al., 2004).”
• Mechanisms of stem cell self-renewal. (2009, background): “Fetal and neonatal HSC maintenance depends on AML1 and Sox17, but these transcription factors are not required for the maintenance of adult HSCs (Ichikawa et al. 2004, Kim et al. 2007, Okuda et al. 1996).”
• Runx1 is required for the endothelial to hematopoietic cell transition but not thereafter (2009, positive): “In summary, the most essential function of Runx1 is during the transition from VEC + cells to Vav + HSCs, although it continues to provide important activity in maintaining normal HSC function and for the terminal differentiation of some lineages 25, 26 (Supplementary Figure 1).”
• Genome-wide Analysis of Simultaneous GATA1/2, RUNX1, FLI1, and SCL Binding in Megakaryocytes Identifies Hematopoietic Regulators (2011, neutral): “…other TFs investigated in this study, GATA2, RUNX1, FLI1, and SCL, have also been previously shown to play important roles in MK differentiation (Growney et al., 2005; Hart et al., 2000; Huang et al., 2009b; Ichikawa et al., 2004; Mik-kola et al., 2003; Song et al., 1999; Spyropoulos et al., 2000).”