Neurod1 is essential for the survival and maturation of adult-born neurons

By Zhengliang Gao, Kerstin Ure, Jessica L Ables, D. Lagace, K. Nave, S. Goebbels, A. Eisch, Jenny Hsieh. 2009

465 citations recorded by the source corpus.

The transcriptional program that controls adult neurogenesis is unknown. We generated mice with an inducible stem cell–specific deletion of Neurod1, resulting in substantially fewer newborn neurons in the hippocampus and olfactory bulb. Thus, Neurod1 is cell-intrinsically required for the survival and maturation of adult-born neurons.

Subfields: Developmental Neuroscience, Molecular Biology, Surgery

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Citations in the corpus

Adult neurogenesis in brain repair: cellular plasticity vs. cellular replacement (2014, background): “New functional neurons are produced under physiological conditions in two neurogenic niches: the subventricular zone (SVZ) in the lateral wall of the lateral ventricles and the subgranular zone (SGZ) of the dentate gyrus (DG) in the hippocampus (Gage, 2000).”
Adult Neurogenesis in the Mammalian Brain: Significant Answers and Significant Questions (2011, background): “In contrast, Prox1 (Lavado et al., 2010), NeuroD (Gao et al., 2009; Kuwabara et al., 2009), and Krü ppel-like factor 9 (Scobie et al., 2009) are sequentially required for maturation and survival of new neurons in the adult hippocampus.”
Adult Neurogenesis in the Hippocampus: From Stem Cells to Behavior. (2016, unknown): “Both transcription factors are direct targets of canonical Wnt signaling (Gao et al., 2009; Kuwabara et al., 2009).”
Neurogenesis in the Adult Hippocampus. (2015, background): “2004), and so are Prox1 and NeuroD1 themselves (Liu et al. 2000; Gao et al. 2009; Karalay et al. 2011).”
Wnt-mediated activation of NeuroD1 and retro-elements during adult neurogenesis (2009, unknown): “, whereas deletion of NeuroD results in decreased survival and maturation of newborn neuron”
Lake-front property: a unique germinal niche by the lateral ventricles of the adult brain. (2011, unknown): “The transcription factors Dlx2, Mash1, and NeuroD1 are all associated with a neurogenic fate, while Olig2 is primarily gliogenic (Parras et al., 2004; Hack et al., 2005; Marshall et al., 2005; Menn et al., 2006; Petryniak et al., 2007; Gao et al., 2009).”
Modeling Hippocampal Neurogenesis Using Human Pluripotent Stem Cells (2014, background): “, 2008), together withNEUROD1, an indispensable transcriptional activator that regulates neuronal differentiation of granule neurons in the hippocampus (Miyata et al., 1999; Liu et al., 2000; Schwab et al., 2000; Gao et al., 2009) (Figure 1F).”
Prospero-related homeobox 1 gene (Prox1) is regulated by canonical Wnt signaling and has a stage-specific role in adult hippocampal neurogenesis (2011, background): “Upon activation of theWnt signaling pathway, a switch in transcription factor occupation on the NeuroD1 promoter may then convert the promoter from a repressed to an activated state, resulting in NeuroD1 expression and allowing for differentiation and survival of newborn granule cells (11, 12).”
RBPJκ-Dependent Signaling Is Essential for Long-Term Maintenance of Neural Stem Cells in the Adult Hippocampus (2010, background): “…reporter mice for the transcription factors SOX2 and NeuroD, which are sequentially expressed in the hippocampal neurogenic lineage where they control NSC maintenance (Favaro et al., 2009; Kuwabara et al., 2009) and neuronal fate commitment (Gao et al., 2009; Kuwabara et al., 2009), respectively.”
Emerging roles of Wnts in the adult nervous system (2010, background): “Recently, NEUROD1 , a pro-neurogenic transcription factor in the adult brain that is selectively expressed in dividing neural progenitors and in immature granule neurons in the adult dentate gyrus, was identified as a downstream effector of Wnts in adult neurogenesi”
A periodic diet that mimics fasting promotes multi-system regeneration, enhanced cognitive performance and healthspan (2015, background): “Microdissected dentate gyrus-enriched samples from FMD mice displayed a major reduction in PKA activity (Figure 4H) and a 2-fold induction in the expression of NeuroD1 (Figure 4I), a transcription factor important for neuronal protection and differentiation (Gao et al., 2009).”
In vivo direct reprogramming of reactive glial cells into functional neurons after brain injury and in an Alzheimer’s disease model (2013, methodology): “Our strategy for reprogramming reactive glial cells into neurons involved construction of a retrovirus encoding NeuroD1, a bHLH proneural transcription factor that plays an important role during embryonic brain development and adult neurogenesis (Cho and Tsai, 2004; Gao et al., 2009; Kuwabara et al.”