Metal Chelation and Inhibition of Bacterial Growth in Tissue Abscesses

By B. Corbin, E. Seeley, A. Raab, Joerg Feldmann, Michael R Miller, Victor J. Torres, K. Anderson, Brian M. Dattilo, P. Dunman, R. Gerads and 4 more. Science, 2008

840 citations recorded by the source corpus.

Subfields: Infectious Diseases, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/7aa9c5e34ed1fbbd95c2e4f51aad8beef2aea047

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In Infectious Diseases

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Citations in the corpus

Nutritional immunity beyond iron: a role for manganese and zinc (2009, background): “aureus infection in mice are severely restricted in manganese and zinc (Figure 1) [10].”
Extracellular DNA Chelates Cations and Induces Antibiotic Resistance in Pseudomonas aeruginosa Biofilms (2008, background): “In principle, cation chelation by DNA is similar to another recently identified host defense mechanism, where the 2+ 2+ Mn and Zn metal chelation properties of the host innateimmune protein calprotectin was shown to limit Staphylococcus aureus growth in tissue abscesses [71].”
Biology of Acinetobacter baumannii: Pathogenesis, Antibiotic Resistance Mechanisms, and Prospective Treatment Options (2017, background): “The innate immune metal-chelating protein calprotectin inhibits bacterial growth by host-mediated chelation of metals, such as zinc (Zn2+ and Zn) and manganese (Mn2+ and Mn) (Corbin et al., 2008).”
Characterization of a new cytotoxin that contributes to Staphylococcus aureus pathogenesis (2010, methodology): “…infection is the formation of abscesses (Ogston, 1882), a battle ground where S. aureus combats leukocytes, the primary and most important line of defence against S. aureus infection (Verdrengh and Tarkowski, 1997; Gresham et al., 2000; LekstromHimes and Gallin, 2000; Corbin et al., 2008).”
Functions of S100 Proteins (2012, background): “Anti-microbial properties, particularly to fungi and Staphylococcus aureus, are chiefly mediated by chelation of Zn and Mn [9,240,241], and when produced by IL-1 -activated keratinocytes, S100A8/S100A9 contributes to the antiinvasive properties of skin [9].”
Cytokine signaling modules in inflammatory responses. (2008, background): “Deletion of Socs3 increases Stat3 signaling from gp130 and, surprisingly, also increases Stat1 signaling leading to an ectopic interferon response (Croker et al., 2003; Lang et al., 2003).”
Staphylococcus aureus leukotoxin ED targets the chemokine receptors CXCR1 and CXCR2 to kill leukocytes and promote infection. (2013, background): “It is however well established that antibody-mediated depletion of PMNs in systemic models of infection renders mice hyper-susceptible to S. aureus-mediated death (Alonzo et al., 2012; Corbin et al., 2008; Gresham et al., 2000).”
Neutrophil Extracellular Traps Contain Calprotectin, a Cytosolic Protein Complex Involved in Host Defense against Candida albicans (2009, background): “The antibacterial and antifungal activity of the complex is reversible by Zn 2 + [29] and does not require direct contact to the microbe [30,31].”
Zinc in Infection and Inflammation (2017, background): “It can inhibit the growth of Staphylococcus aureus by sequestering zinc as well [95].”
S100A8/A9 in Inflammation (2018, background): “S100A8/A9 in mucosal fluids, airway secretions, gingival crevicular fluid, and tissue abscesses contribute to the limitation of commensal microorganism growth and prevention against the intrusion of pathogens (89).”