Metalloproteinases: role in breast carcinogenesis, invasion and metastasis
By M. Duffy, T. Maguire, A. Hill, E. McDermott, N. O’higgins. Breast Cancer Research, 2000
644 citations recorded by the source corpus.
The matrix metalloproteinases (MMPs) are a family of zinc-dependent endopeptidases. Their primary function is degradation of proteins in the extracellular matrix. Currently, at least 19 members of this family are known to exist. Based on substrate specificity and domain organization, the MMPs can be loosely divided into four main groups: the interstitial collagenases, gelatinases, stromelysins and membrane-type MMPs. Recent data from model systems suggest that MMPs are involved in breast cancer initiation, invasion and metastasis. Consistent with their role in breast cancer progression, high levels of at least two MMPs (MMP-2 and stromelysin-3) have been found to correlate with poor prognosis in patients with breast cancer. Because MMPs are apparently involved in breast cancer initiation and dissemination, inhibition of these proteinases may be of value both in preventing breast cancer and in blocking metastasis of established tumours
Subfields: Cancer Research, Genetics, Oncology
View Paper: https://www.semanticscholar.org/paper/7a4076e30812d3d8642d75738fd9fe9fa25dbd95
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Citations in the corpus
- IL-6 triggers malignant features in mammospheres from human ductal breast carcinoma and normal mammary gland. (2007, background): “MMP-2 activity was determined by gelatin zymography.”
- Reactive oxygen species in tumor progression. (2005, background): “1885 and metastasis of some cancers (55, 56).”