Aggregated neutrophil extracellular traps limit inflammation by degrading cytokines and chemokines
By C. Schauer, C. Janko, L. Munoz, Yi Zhao, D. Kienhöfer, B. Frey, M. Lell, B. Manger, J. Rech, E. Naschberger and 8 more. Nature Medicine, 2014
913 citations recorded by the source corpus.
Subfields: Immunology, Molecular Biology, Pulmonary and Respiratory Medicine
View Paper: https://www.semanticscholar.org/paper/1335d8fa6ccb7e39227aa6c9716834dfd8dd1d9e
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In Molecular Biology
Citations in the corpus
- Neutrophil Extracellular Traps and Its Implications in Inflammation: An Overview (2017, background): “Autoimmunity is triggered by cPR-3(105-201), a protein complementary to human autoantigen proteinase-3.”
- Neutrophil: A Cell with Many Roles in Inflammation or Several Cell Types? (2018, background): “As such, these aggNETs block MSU crystals and also trap and degrade pro-inflammatory mediators by serine proteases attached to the DNA fibers (Schauer et al., 2014).”
- Neutrophils: Between Host Defence, Immune Modulation, and Tissue Injury (2015, background): “Although NET generation has been described initially as an antimicrobial mechanism, recent data suggest that NETs could play a more important role in autoimmune and autoinflammatory pathologies, such as vasculitis [71], lung injury [72,73], atherosclerosis [74], rheumatoid arthritis [75,76], thrombo”
- The Tumor Microenvironment Innately Modulates Cancer Progression (2019, background): “These proteases degrade proinflammatory cytokines and reposition the TME to enhance tumor progression and aid in metastasis (36).”