Breaking the cycle: treatment strategies for 163 cases of recurrent Clostridium difficile disease

By L. Mcfarland, G. Elmer, C. Surawicz. American Journal of Gastroenterology, 2002

741 citations recorded by the source corpus.

Subfields: Gastroenterology, Infectious Diseases

View Paper: https://www.semanticscholar.org/paper/79f22a9507557ca4b4a2406c7af5dfd86b6092a0

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Gastroenterology

1. J. Bartlett

In Infectious Diseases

1. Janet K. Jansson
2. A. Khoruts
3. J. Bartlett
4. J. H. Morse

Citations in the corpus

• Decreased diversity of the fecal Microbiome in recurrent Clostridium difficile-associated diarrhea. (2008, background): “difficile antibiotics or the administration of probiotic organisms— have been tried for treatment of RCD [12, 13] [14].”
• Changes in the Composition of the Human Fecal Microbiome After Bacteriotherapy for Recurrent Clostridium difficile-associated Diarrhea (2009, background): “Most cases of the CDAD respond to the treatment with metronidazole or vancomycin.(1,10,11) However, recurrence of the infection occurs in about 20% of cases, and it is typically caused by regrowth of vegetative C.”
• Narrative Review: The New Epidemic of Clostridium difficileAssociated Enteric Disease (2006, methodology): “Several methods are used to treat relapsing disease, including biotherapy or probiotics (such as Saccharomyces boulardii and Lactobacillus rhamnosus GG) (58–61), stool implants (62), immunotherapy (intravenous immunoglobulin) (48, 49), and tapering or pulse dosing of oral vancomycin (54, 61).”
• European Society of Clinical Microbiology and Infectious Diseases: update of the treatment guidance document for Clostridium difficile infection. (2014, background): “[69] Vancomycin 1–2 g/day 14 71 59 days Vancomycin <1 g/day 48 54 59 days Vancomycin ≥2 g/day 21 43 59 days Vancomycin taper 29 31 80 days Vancomycin pulse 7 14 80 days Metronidazole <1 g/day 29 45 59 days Metronidazole 1.”
• Clinical Practice Guidelines for Clostridium difficile Infection in Adults and Children: 2017 Update by the Infectious Diseases Society of America (IDSA) and Society for Healthcare Epidemiology of America (SHEA). (2018, neutral): “Second or subsequent CDI recurrences may be treated with oral vancomycin as a tapered and pulsed-dose regimen as described above [350].”
• Asymptomatic carriers are a potential source for transmission of epidemic and nonepidemic Clostridium difficile strains among long-term care facility residents. (2007, neutral): “A previous study found that as many as one-half of patients with CDAD continued to excrete spores in stool after resolution of diarrhea [26].”