Molecular and electrophysiological evidence for net synaptic potentiation in wake and depression in sleep

By V. Vyazovskiy, Chiara Cirelli, M. Pfister‐Genskow, Ugo Faraguna, Giulio Tononi. Nature Neuroscience, 2008

825 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Cognitive Neuroscience

View Paper: https://www.semanticscholar.org/paper/79e7fcde24c854fa5ceae11a638e09742ccee363

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In Cellular and Molecular Neuroscience

In Cognitive Neuroscience

Citations in the corpus

Plasticity during Sleep Is Linked to Specific Regulation of Cortical Circuit Activity (2017, background): “Importantly, whereas sleep globally reduced levels of AMPA receptors (Vyazovskiy et al., 2008), a small fraction of spines showed increased AMPA receptor levels after sleep.”
Neuromodulation of brain states. (2012, neutral): “At the synaptic level, some studies found net synaptic strengthening during wakefulness and depression during sleep (Vyazovskiy et al., 2008).”
Synaptic energy use and supply. (2012, neutral): “…to sleep), GluR1 subunits of AMPA receptors are present at a higher level and in a more phosphorylated state (consistent with an increased synaptic strength), synaptic currents and spine numbers increase, and evoked neuronal responses are larger (Vyazovskiy et al., 2008; Maret et al., 2011).”
Sleep and synaptic renormalization: a computational study. (2010, background): “…link 91 between plasticity and sleep SWA is shown, for example, by the observation that electrophysiological 92 markers of synaptic strength, such as the amplitude and slope of field potentials evoked during 93 wakefulness, correlate with SWA values during subsequent sleep (Vyazovskiy et al. 2008).”
Regional aerobic glycolysis in the human brain (2010, background): “Together these two studies provide a tentative link between the metabolism of learning-induced biosynthesis and a hypothesis that associates wakefulness with synaptic potentiation and sleep with synaptic renormalization (55, 56), a process that has been associated with changes in brain glucose consu”
Cortical firing and sleep homeostasis. (2009, background): “Another possibility is that changes in neuronal firing and synchrony reflect a progressive, net increase in the strength of cortico-cortical connections during wakefulness, followed by a gradual net decrease during sleep (Tononi and Cirelli, 2006), as suggested by some recent studies (Bellina et al.”
The sleep-wake cycle regulates brain interstitial fluid tau in mice and CSF tau in humans (2019, background): “As neuronal synaptic strength/connectivity is higher during wakefulness than during sleep (11, 12), we asked whether tau levels in the brain interstitial fluid (ISF) varied with the sleep-wake cycle.”
Neurophysiological and Computational Principles of Cortical Rhythms in Cognition (2010, background): “In fact, there is evidence that excitatory synaptic connections in the cortex are overall depressed in sleep and potentiated in wakefulness (1019), suggesting that a primary function of slow-wave sleep is homeostatic regulation of synaptic circuitry (283, 655, 959).”
Network-timing-dependent plasticity (2015, background): “…solution, and may have implications for the mechanisms underlying pathological network states that occur in epilepsy (Trasande and Ramirez, 2007) as well as the down-scaling of synaptic weights during slow-wave sleep (Massimini and Amzica, 2001; Tononi and Cirelli, 2006; Vyazovskiy et al., 2008).”