Cortical firing and sleep homeostasis.

By V. Vyazovskiy, Umberto Olcese, Yaniv M. Lazimy, Ugo Faraguna, S. Esser, Justin C. Williams, Chiara Cirelli, Giulio Tononi. Neuron, 2009

722 citations recorded by the source corpus.

The need to sleep grows with the duration of wakefulness and dissipates with time spent asleep, a process called sleep homeostasis. What are the consequences of staying awake on brain cells, and why is sleep needed? Surprisingly, we do not know whether the firing of cortical neurons is affected by how long an animal has been awake or asleep. Here, we found that after sustained wakefulness cortical neurons fire at higher frequencies in all behavioral states. During early NREM sleep after sustained wakefulness, periods of population activity (ON) are short, frequent, and associated with synchronous firing, while periods of neuronal silence are long and frequent. After sustained sleep, firing rates and synchrony decrease, while the duration of ON periods increases. Changes in firing patterns in NREM sleep correlate with changes in slow-wave activity, a marker of sleep homeostasis. Thus, the systematic increase of firing during wakefulness is counterbalanced by staying asleep.

Subfields: Cellular and Molecular Neuroscience, Cognitive Neuroscience, Endocrine and Autonomic Systems

View Paper: https://www.semanticscholar.org/paper/4961dbbfed6cda698a3d1d76ff20971264966404

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Citations in the corpus

Local sleep in awake rats (2011, background): “At the beginning of the task, hits and misses alternated regularly, but as time progressed, long clusters of misses became more frequent and had increasingly variable duration (duration, F(2,32) 5 4.”
Sleep and synaptic renormalization: a computational study. (2010, methodology): “Furthermore, 729 when the model entered the sleep mode, longer periods of prior wakefulness produced increased 730 activity, synchrony and sleep SWA, in line with experimental results (Vyazovskiy et al., 2009).”
Firing Rate Homeostasis in Visual Cortex of Freely Behaving Rodents (2013, background): “…is how a homeostatic activity target can be implemented in a network that operates under very different sensory and modulatory conditions during different behavioral states 340 Neuron 80, 335–342, October 16, 2013 ª2013 Elsevier Inc. (Steriade and Timofeev, 2003; Vyazovskiy et al., 2009).”
Sleep and the Price of Plasticity: From Synaptic and Cellular Homeostasis to Memory Consolidation and Integration (2014, background): “In a recent study (Grosmark et al., 2012), firing rates of hippocampal CA1 neurons decreased across sleep, as they do in cortex (Vyazovskiy et al., 2009) but did so in REM sleep as a function of REM theta power and not, as they do in cortex, in NREM sleep as a function of SWA (Vyazovskiy et al.,…”
The temporal structures and functional significance of scale-free brain activity (2010, positive): “The surface positive (phase 0) ECoG activity at 1 Hz corresponds to the intracellular ‘‘up-state,’’ during which higherfrequency activities are dramatically increased (Vyazovskiy et al., 2009).”
Sleep State Switching (2010, background): “This relationship suggests that the slowwave activity is homeostatically controlled and reflects sleep drive (Vyazovskiy et al., 2009).”
Regional slow waves and spindles in human sleep. (2011, positive): “…recording from 8–12 brain structures directly, the current results establish that slow waves indeed propagate in the human brain as previously suggested (Massimini et al., 2004; Murphy et al., 2009), and as observed in part in rodents (Vyazovskiy et al., 2009a) and cats (Volgushev et al., 2006).”
Plasticity during Sleep Is Linked to Specific Regulation of Cortical Circuit Activity (2017, background): “This is indicated by neuronal firing rate measurements in rodents (Vyazovskiy et al., 2009; Grosmark et al., 2012; Miyawaki and Diba, 2016) and by measurements of cortical excitability through transcranial magnetic stimulation (TMS) in humans (Civardi et al.”
Automated long-term recording and analysis of neural activity in behaving animals (2016, background): “…1964; Lee and Dan, 2012; Peña et al., 1999; Santhanam et al., 2007; Steriade et al., 1974; Vyazovskiy et al., 2009), inter-spike interval distributions (Mahon et al., 2006; Vyazovskiy et al., 2009), and neural synchrony (Gervasoni et al., 2004; Ribeiro et al., 2004; Wilson and McNaughton, 1994).”
REM Sleep Reorganizes Hippocampal Excitability (2012, positive): “…neurons increased during the wake-active cycle, accompanied by increased synchrony of the recorded neurons, whereas both firing rates and synchrony decreased during the sleep cycle (Vyazovskiy et al., 2009), largely in accordance with the in vitro synaptic ''scaling'' model (Turrigiano, 1999).”