Functional assembly of engineered myocardium by electrical stimulation of cardiac myocytes cultured on scaffolds

By M. Radišić, Hyoungshin Park, Helen Shing, T. Consi, F. Schoen, Robert Langer, L. Freed, G. Vunjak‐Novakovic. Proceedings of the National Academy of Sciences of the United States of America, 2004

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Bioprinting 3D microfibrous scaffolds for engineering endothelialized myocardium and heart-on-a-chip (2016, positive): “Indeed, the presence of organized sarcomeric ban ding and the formation of a large number of gap junctions provided evidence of the ma turation of the cardiomyocytes and represented a critical basis for generating synchro nous beating of the cardiac constructs [2, 59-61].”
Nanoscale cues regulate the structure and function of macroscopic cardiac tissue constructs (2009, methodology): “A variety of methods such as mechanical stretching (12), microcontact printing (13), and electrical stimulation (14) have been used to engineer better organized cardiomyocyte cultures.”
Review on Cell Mechanics: Experimental and Modeling Approaches (2013, methodology): “They have also been used to determine the effect of electrical gradients on cytoskeletal orientation and organization [358,361,366–368], as well as cellular contraction [367] [368] [369] [370].”
Regenerating the heart (2005, background): “, as well as hypertrophy in response to electrical stimulatio”
Tissue Engineering by Self-Assembly of Cells Printed into Topologically Defined Structures (2007, neutral): “29 To measure the amplitude of contractions, video-recorded beating sequences were digitized at the rate of 30 frames/ second.”