Mitochondrial genome variation and the origin of modern humans

By Max Ingman, Henrik Kaessmann, Svante Pääbo, U. Gyllensten. Nature, 2000

1,471 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/790675e73337d9c447c0290c5b5941a9b7f6b55e

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Citations in the corpus

Craniofacial Feminization, Social Tolerance, and the Origins of Behavioral Modernity (2014, background): “…in mtDNA in living humans, strongly suggest that the earliest members of our species appeared in Africa between 200–150 Ka BP (Cann, Stoneking, and Wilson 1987; Forster 2004; Ingman et al. 2000; McDougall, Brown, and Fleagle 2005; White et al. 2003), some time during the earlier part of the MSA.”
Human Y-chromosomal variation in European populations (2004, background): “Many studies have shown that African populations harbour more genetic diversity than non-African populations in mtDNA (Cann et al. 1987; Vigilant et al. 1991; Ingman et al. 2000), in Y chromosome microsatellites and biallelic markers (Seielstad et al.”
A Mitochondrial Paradigm of Metabolic and Degenerative Diseases, Aging, and Cancer: A Dawn for Evolutionary Medicine (2005, positive): “Evidence that climatic adaptation has influenced the geographic distribution of mtDNA diversity was first obtained from analyzing the amino acid replacement (nonsynonymous, NS) (Ka) to silent (synonymous, S) (Ks) mutation ratios (Ka/Ks) from the 13 mtDNA open reading frames (83, 239).”
Pleistocene Homo sapiens from Middle Awash, Ethiopia (2003, background): “The Herto crania fail to confirm such ‘multiregional’ speculation and conform more closely to most molecular prediction”
Early human use of marine resources and pigment in South Africa during the Middle Pleistocene (2007, background): “The LC-MSA Upper is a heavily cemented zone with three sub-units: (1) a lower hard sandy and silty layer containing reworked ashes that directly contacts and transitions into the richer anthropogenic deposits of the LC-MSA Middle; (2) a layer of shellfish stratified within an aeolian dune with a wei”
A coalescent-based method for detecting and estimating recombination from gene sequences. (2002, methodology): “(Ingman et al. 2000; Worobey 2001) to freely recombin- Hypermutable: Most sites (99.5”
The origin and evolution of model organisms (2002, background): “Furthermore, knowing when humans and chimpanzees diverged from one another allows researchers to calibrate the rates of genetic change in modern humans and to estimate when populations migrated to different regions of the Worl”
Mitochondrial DNA mutations and human disease. (2010, background): “Most mtDNA alterations are neutral polymorphisms, which have proved useful in tracking human migrations [53].”
Coastal South Africa and the Coevolution of the Modern Human Lineage and the Coastal Adaptation (2011, background): “Evolutionary genetics (Ingman et al. 2000; Tishkoff et al. 2007; Gonder et al. 2007; Fagundes et al. 2007; Behar et al. 2008) point to the time between 200 and 100 ka as the origin point for the modern human lineage.”
Linkage disequilibrium in the human genome (2001, background): “Alternatively, the long-range LD could be due to a severe bottleneck that occurred during the founding of Europe or during the dispersal of anatomically modern humans from Afric”
Mitochondrial mutations in cancer (2006, background): “…the synonymous tumorspecific somatic mRNA gene mutations encompass five transversions and 40 transitions (Table 3), consistent with the predominance of transition mutations found in inter-specific and intra-specific population studies (Brown et al., 1982; Ingman et al., 2000; Mishmar et al., 2003).”
Towards the understanding of post-glacial spread of human mitochondrial DNA haplogroups in Europe and beyond: a phylogeographic approach (2004, methodology): “The lack of L3 lineages other than M and N among non-Africans (Ingman et al. 2000; Herrnstadt et al. 2002; Kivisild et al. 2002) and, particularly, in South Asia, suggests that the earliest migration(s) of modern humans already carried these two mtDNA ancestors (Kivisild et al. 2003b).”
mtDB: Human Mitochondrial Genome Database, a resource for population genetics and medical sciences (2005, background): “Since 2000, with the publication of the first comprehensive study on complete human mitochondrial genome sequences (5), the amount of data available from mitochondrial genomes has been growing rapidly.”