Linkage disequilibrium in the human genome

By David Reich, M. Cargill, S. Bolk, J. Ireland, Pardis C Sabeti, D. Richter, T. Lavery, Rose Kouyoumjian, S. Farhadian, R. Ward and 1 more. Nature, 2001

1,815 citations recorded by the source corpus.

Subfields: Genetics, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/3638a139b3994b447c4f89d24a96524558a41258

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Citations in the corpus

Identifying Causal Variants at Loci with Multiple Signals of Association (2014, background): “The linkage disequilibrium (LD) (Pritchard and Przeworski 2001; Reich et al. 2001) structure of the human genome has greatly benefited GWAS in interrogating only a subset of all variants to assay common variation across the genome.”
Variations in GABRA2, encoding the alpha 2 subunit of the GABA(A) receptor, are associated with alcohol dependence and with brain oscillations. (2004, result): “This is consistent with other data on LD across the human genome (Daly et al. 2001; Goldstein 2001; Reich et al. 2001; Gabriel et al. 2002).”
Novel genetic mapping tools in plants: SNPs and LD-based approaches (2002, background): “Recent data indicate that in European human populations, LD extends at least to 60 kb [ 24 ].”
Bayesian haplotype inference for multiple linked single-nucleotide polymorphisms. (2002, methodology): “2001a) and of the genomewide LD in populations with different histories (Reich et al. 2001).”
Leveraging polygenic enrichments of gene features to predict genes underlying complex traits and diseases (2020, background): “First, linkage disequilibrium (LD) between variants masks the identity of the causal variant 4 .”
Calibrating a coalescent simulation of human genome sequence variation. (2005, background): “22 relative to the source population) (Reich et al. 2001); we were unable to find models in which this parameter was outside the range of ∼0.”
The linkage disequilibrium and the selection of genetic markers for association studies in European populations (2007, background): “…regions of the human genome – close markers are not always in strong LD (Ardlie et al. 2001; Clark et al. 1998; Moffatt et al. 2000) and sometimes LD has been reported between quite distant markers (Abecasis et al. 2001; Daly et al. 2001; Gabriel et al. 2002; Patil et al. 2001; Reich et al. 2001).”
International Union of Pharmacology. XLV. Classification of the Kinin Receptor Family: from Molecular Mechanisms to Pathophysiological Consequences (2005, background): “Thus, a genetic marker in one gene could be in linkage disequilibrium with a functional alteration of the other (see Houle et al., 2000a) because there is little probability of recombination within zones of 60 kb in the human genome (Reich et al., 2001).”