D-serine is an endogenous ligand for the glycine site of the N-methyl-D-aspartate receptor.
By J. Mothet, A. Parent, Herman Wolosker, R. Brady, D. Linden, C. D. Ferris, M. Rogawski, S. Snyder. Proceedings of the National Academy of Sciences of the United States of America, 2000
1,152 citations recorded by the source corpus.
Subfields: Biochemistry, Cellular and Molecular Neuroscience, Spectroscopy
View Paper: https://www.semanticscholar.org/paper/7905bd99a4eba1155af208d74927a60530b625c9
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In Biochemistry
- Philip Haydon
- David Attwell
- Giorgio Carmignoto
- N. J. Allen
- C. Eroglu
- Alexei Verkhratsky
- Maiken Nedergaard
In Cellular and Molecular Neuroscience
- Philip Haydon
- Giorgio Carmignoto
- Stephane Oliet
- N. Hamilton
- David Attwell
- S. Lipton
- Maiken Nedergaard
- Alexei Verkhratsky
Citations in the corpus
- Do astrocytes really exocytose neurotransmitters? (2010, background): “However, it has become clear that D -serine is often the physiological agonist at the 'glycine site”
- Paradigm shift in neuroprotection by NMDA receptor blockade: Memantine and beyond (2006, background): “Although levels of glycine are tenfold higher than D -serine, recent reports indicate that endogenous D -serine and not glycine is the dominant endogenous co-agonist for NMDAR-mediated neurotoxicit”
- Glia-derived D-serine controls NMDA receptor activity and synaptic memory. (2006, background): “, 2003), it is now obvious that another important gliotransmitter is the amino acid D-serine (Mothet et al., 2000), which serves as a ligand at the strychnine-insensitive glycine site of NMDA receptors (NMDARs; Johnson and Ascher, 1987).”
- Regulation of extrasynaptic signaling by polysialylated NCAM: Impact for synaptic plasticity and cognitive functions (2017, background): “Notably, the functional activation of NMDARs requires the simultaneous binding of its agonist glutamate and one of its two co-agonists, namely glycine (Forsythe et al., 1988; Johnson and Ascher, 1987) and D-serine (Henneberger et al., 2010; Mothet et al., 2000).”
- Synaptic and extrasynaptic NMDA receptors are gated by different endogenous coagonists. (2012, background): “Such agonist applications yielded longlasting outward currents which resulted from the activation of both synaptic and extrasynaptic NMDARs (Harris and Pettit, 2007; Mothet et al., 2000).”
- Dynamic signaling between astrocytes and neurons. (2001, background): “Recent work has reported that D-serine is an endogenous ligand of the glycine site of N-methyl-D-aspartate (NMDA) receptors responsible for modulating NMDA receptor-mediated synaptic transmission in cultured hippocampal neurons (74).”