Precursors of Functional MHC Class I- or Class II-Restricted CD8αα+ T Cells Are Positively Selected in the Thymus by Agonist Self-Peptides

By A. Leishman, L. Gapin, M. Capone, E. Palmer, H. Macdonald, M. Kronenberg, Hilde Cheroutre. 2002

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Self-reactivity in thymic double-positive cells commits cells to a CD8αα lineage with characteristics of innate immune cells (2004, result): “The last results are reminiscent of the enhanced selection of CD8αα intraepithelial lymphocytes (IELs) in the H-Y male mic”
T cell receptor signal strength in Treg and iNKT cell development demonstrated by a novel fluorescent reporter mouse (2011, background): “CD4+Foxp3+ regulatory T cells (Treg cells), invariant NKT cells (iNKT cells), and CD8+ intraepithelial lymphocytes (IELs) are hypothesized to be positively selected via strong TCR signals in the thymus (Leishman et al., 2002; Godfrey et al., 2004; Zhou et al., 2004).”
Gut Immune Maturation Depends on Colonization with a Host-Specific Microbiota (2012, background): “…expanded absolute numbers of CD8aa-abTCR IELs—a unique self-reactive population that requires exposure to self-agonists for selection in the thymus (Leishman et al., 2002)—but only partially expanded the CD8ab-abTCR IELs, which is generated mostly in secondary lymphoid organs and is primed…”