TACI and BAFF-R mediate isotype switching in B cells

By E. Castigli, S. Wilson, Sumi Scott, F. Dedeoğlu, Shengli Xu, K. Lam, R. Bram, H. Jabara, R. Geha. Journal of Experimental Medicine, 2005

595 citations recorded by the source corpus.

The tumor necrosis factor family members BAFF and APRIL induce Ig isotype switching in human B cells. We analyzed the ability of BAFF and APRIL to induce isotype switching in murine B cells to IgG1, IgA, and IgE. APRIL and BAFF each engage two receptors, transmembrane activator and calcium-modulator and cytophilin ligand interactor (TACI) and B cell maturation antigen (BCMA), on B cells. In addition, BAFF engages a third receptor on B cells, BAFF-R. To determine the role of these receptors in isotype switching, we examined B cells from mice deficient in TACI, BCMA, and BAFF-R. The results obtained indicate that both TACI and BAFF-R are able to transduce signals that result in isotype switching.

Subfields: Immunology

View Paper: https://www.semanticscholar.org/paper/78d00dc981b933a3dacc19bbd76ed1a5df45bc34

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Citations in the corpus

• Germinal centres: role in B-cell physiology and malignancy (2008, background): “, transmembrane activator and calcium-modulating cyclophilin-ligand interactor (TACI) and B-cell-activating factor receptor (BAFFR”
• Mutations in TNFRSF13B encoding TACI are associated with common variable immunodeficiency in humans (2005, background): “, which is mediated, at least partly, by the interaction of APRIL with TAC”
• Mechanism and regulation of class switch recombination. (2008, background): “B cell activating factor (BAFF) can synergize with IL-4 to induce AID expression in CD40−/− B cells in culture (218).”
• Cracking the BAFF code (2009, background): “Specifically, APRIL and BAFF mediate CD40-independent class switching to IgA through both TACI and BAFF”
• Toll-like receptor signalling in the intestinal epithelium: how bacterial recognition shapes intestinal function (2010, background): “APRIL binds to transmembrane activator and calcium-modulating cyclophilin-ligand interactor (TACI) on B cells to induce plasma cell survival and class switchin”
• TACI is mutant in common variable immunodeficiency and IgA deficiency (2005, background): “This class switch recombination requires two signals: one signal is normally delivered by cytokines, and the second signal is normally delivered by select members of the tumor necrosis factor receptor family expressed on B cells that include CD40, TACI and BAFF-R (B cell–activating factor of the tum”
• The regulation of IgA class switching (2008, background): “In the presence of other cytokines, BAFF and APRIL induce germline C α gene expression, AID expression and IgA class switching in a CD40-independent manne”