Driving fast-spiking cells induces gamma rhythm and controls sensory responses

By Jessica A. Cardin, M. Carlén, K. Meletis, Ulf Knoblich, Feng Zhang, Feng Zhang, Karl Deisseroth, Li-Huei Tsai, C. Moore. Nature, 2009

2,642 citations recorded by the source corpus.

Cortical gamma oscillations (20-80 Hz) predict increases in focused attention, and failure in gamma regulation is a hallmark of neurological and psychiatric disease. Current theory predicts that gamma oscillations are generated by synchronous activity of fast-spiking inhibitory interneurons, with the resulting rhythmic inhibition producing neural ensemble synchrony by generating a narrow window for effective excitation. We causally tested these hypotheses in barrel cortex in vivo by targeting optogenetic manipulation selectively to fast-spiking interneurons. Here we show that light-driven activation of fast-spiking interneurons at varied frequencies (8-200 Hz) selectively amplifies gamma oscillations. In contrast, pyramidal neuron activation amplifies only lower frequency oscillations, a cell-type-specific double dissociation. We found that the timing of a sensory input relative to a gamma cycle determined the amplitude and precision of evoked responses. Our data directly support the fast-spiking-gamma hypothesis and provide the first causal evidence that distinct network activity states can be induced in vivo by cell-type-specific activation.

Subfields: Cellular and Molecular Neuroscience, Cognitive Neuroscience

View Paper: https://www.semanticscholar.org/paper/78b495a6f48863ed5d8445af0a71c05bbe285049

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Citations in the corpus

Closed-loop and activity-guided optogenetic control. (2015, positive): “…of experimental drive can easily be increased where desired with high-intensity and briefer light or diminished with reduced light intensity (Cardin et al., 2009), or entirely eliminated in favor of subthreshold biasing of excitability of the target population (which then fire…”
Arousal and locomotion make distinct contributions to cortical activity patterns and visual encoding (2014, positive): “A change in arousal might therefore not exclusively account for the increase in gamma-band power during locomotion periods, suggesting that locomotion might further amplify gamma-band oscillations through the increased drive of local RS and FS cells (Cardin et al., 2009; Csicsvari et al., 2003; Soha”
The Development and Application of Optogenetics (2011, methodology): “Reports on the functions of parvalbumin-expressing fast-spiking interneurons demonstrated directly their involvement in gamma oscillations and information processing in mouse prefrontal (Sohal et al. 2009) and somatosensory (Cardin et al. 2009, 2010) cortex.”
Inhibitory Plasticity Dictates the Sign of Plasticity at Excitatory Synapses (2014, background): “…House et al., 2011; Chen et al., 2012), circuit excitability (Ben-Ari, 2006; Fritschy, 2008; Carvalho and Buonomano, 2009; Clarkson et al., 2010), learning (Kano, 1995; Fritschy and Brünig, 2003; Ruediger et al., 2011), and sensory processing (Cardin et al., 2009; Isaacson and Scanziani, 2011).”
Biological Psychology : Stress (2016, positive): “…2008), but recent evidence emphasises interactions between interneurons and pyramidal cells and the centrality of the role of the NMDA receptor in production of cortical oscillations (Cardin et al., 2009; Carlen et al., 2012; Carracedo et al., 2013; Kirli, Ermentrout, & Cho, 2014; Sivarao, 2015).”
Remote control of neuronal activity in transgenic mice expressing evolved G protein-coupled receptors. (2009, positive): “These findings indicate that CNO-induced activation of hM3Dq depolarizes and increases the firing rate of CA1 pyramidal neurons through a PLC-dependent mechanism.”
Common circuit defect of excitatory-inhibitory balance in mouse models of autism (2009, positive): “Most recently, direct optical activation of PV-cells is shown to be sufficient for inducing γ -rhythms and controlling sensory responses to enhance cortical circuit performance [48, 49].”
Mechanisms of Gamma Oscillations (2012, background): “2 channels (Lien & Jonas 2003), (d ) a unique spike-conductance trajectory (Tateno & Robinson 2009), and (e) resonance at gamma frequency in response to stochastic excitatory conductance inputs (Figure 4) (Pike et al. 2000, Cardin et al. 2009, Sohal et al. 2009).”