Muscle fatigue: lactic acid or inorganic phosphate the major cause?

By H. Westerblad, D. Allen, J. Lännergren. News in Physiological Sciences - NIPS, 2002

647 citations recorded by the source corpus.

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Repeated-Sprint Ability — Part I (2011, background): “In vitro studies provide evidence that increased inorganic phosphate levels affect calcium release from the sarcoplasmic reticulum and/or myofibrillar calcium sensitivity, which in turn decrease the number of strong binding cross-bridges.([120,121]) However, whether this scenario occurs during RSE i”
Skeletal muscle fatigue: cellular mechanisms. (2008, background): “Accordingly, increased Pi is considered to be a major cause of fatigue (470).”
Biochemistry of exercise-induced metabolic acidosis. (2004, background): “14B clearly shows that the origin of the accumulating intramuscular Pi is ATP hydrolysis, not creatine phosphate breakdown, which is still mistakenly interpreted by many physiologists (59).”
Exercise-Induced Oxidative Stress: Cellular Mechanisms and Impact on Muscle Force Production (2008, methodology): “For the purpose of this discussion, we will define muscular fatigue as “an exercise-induced reduction in muscle force generation” (120, 404).”
Lactate metabolism: a new paradigm for the third millennium (2004, background): “Particularly over the last 10 years, the role of acidosis as an important cause of fatigue has been challenged (see Westerblad et al. 2002).”