Lactate metabolism: a new paradigm for the third millennium

By L. Gladden. Journal of Physiology, 2004

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Lactobacillus plantarum promotes Drosophila systemic growth by modulating hormonal signals through TOR-dependent nutrient sensing. (2011, background): “Indeed, lactic acid or lactate in its reduced form is a particularly mobile fuel for aerobic metabolism, and recent evidence reveals that eukaryote lactate dehydrogenase produces pyruvate that in turn fuels the mitochondrial Krebs cycle to produce energy (Gladden, 2004).”
Activity‐dependent regulation of energy metabolism by astrocytes: An update (2007, background): “Few seemed to have correctly grasped this message (but see Gladden, 2004) whereas many others have clearly expressed their opposition to what appears to be an incorrectly perceived and/or portrayed view (Chih and Roberts, 2003; Chih et al., 2001; Dienel and Cruz, 2004; Dienel and Hertz, 2001;…”
The Science and Translation of Lactate Shuttle Theory. (2018, background): “…cellular organelles found in virtually all eukaryotic cells that are involved in catabolism of substances such as very-long-chain (i.e., C22 and longer) fatty acids, branchedchain fatty acids, D-amino acids, poly amines, and reactive oxygen species such as hydrogen peroxide (H2O2) (Gladden, 2004).”