Biochemistry of exercise-induced metabolic acidosis.

By R. Robergs, F. Ghiasvand, D. Parker. American Journal of Physiology. Regulatory Integrative and Comparative Physiology, 2004

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Endurance exercise performance: the physiology of champions (2008, background): “…glycogenolysis and glycolysis and ultimately the rate of pyruvate delivery to the mitochondria progressively exceeds the ability of the mitochondria to oxidize pyruvate and this leads to accelerated generation of lactic acid (Holloszy et al. 1977; Holloszy & Coyle, 1984; Robergs et al. 2004).”
Comparative Physiology of Fasting, Starvation, and Food Limitation (2012, background): “2005), lactate production and acidification of muscle cells and blood coincide (Robergs et al. 2004).”
Lactate Regulates Metabolic and Pro-inflammatory Circuits in Control of T Cell Migration and Effector Functions (2015, background): “2), most of the lactate is deprotonated and is present in the negatively charged, biologically active form as lactate anion [13].”
The Acidic Tumor Microenvironment as a Driver of Cancer. (2019, background): “hydrolysis adds considerably to acidification in skeletal muscle cells under intense exercise (49).”
The Science and Translation of Lactate Shuttle Theory. (2018, background): “Fairly recently also, the idea has been advanced that glycolysis is pH neutral because it produces lactate anion, as opposed to lactic acid (Hochachka and Mommsen, 1983; Robergs et al., 2004).”