Elevated copper and oxidative stress in cancer cells as a target for cancer treatment.

By A. Gupte, R. Mumper. Cancer Treatment Reviews, 2009

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Copper homeostasis and cuproptosis in health and disease (2022, background): “Potential therapeutic strategies for targeting cuproptosis in cancer In recent decades, a growing body of evidence suggests that the Cu-complex might serve as a potential therapeutic target for treating cancer, as Cu has been shown to promote the death of cancer cells via apoptosis and/or an accumul”
Copper in diseases and treatments, and copper‐based anticancer strategies (2009, background): “The remarkable metabolic changes that have long been known to occur in cancer cells have been associated, among other factors, with copper handling and copper utilizing proteins.(124) Since the discovery that respiratory capacity is down-regulated in many cancer cell types,(125) mechanisms underlyin”
Role of Reactive Oxygen Species in Cancer Progression: Molecular Mechanisms and Recent Advancements (2019, background): “Moreover, copper was reported to increase the ROS-mediated expression of VEGF, HiF-1α, and G-protein estrogen receptor (GPER) in HepG2 hepatocellular carcinoma cells and SkBr3 breast cancer cells via activation of the EGFR/ERK/c-Fos pathway [83,84].”