Nitric oxide plays a critical role in suppression of T-cell proliferation by mesenchymal stem cells.

By Kazuya Sato, K. Ozaki, I. Oh, A. Meguro, K. Hatanaka, T. Nagai, K. Muroi, K. Ozawa. Blood, 2007

967 citations recorded by the source corpus.

Subfields: Genetics, Immunology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/77a7b83305edb6966ea8bdb9c47dbd2ce606a1ec

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In Genetics

1. N. Singer
2. R. Lee
3. A. Caplan
4. C. Gregory
5. L. Meirelles
6. Jeffrey L Spees

In Molecular Biology

1. C. Gregory
2. A. Caplan
3. Jeffrey L Spees
4. R. Lee

Citations in the corpus

• Mechanisms involved in the therapeutic properties of mesenchymal stem cells. (2009, background): “focused on the expression of inducible nitric oxide synthase (iNOS) by murine MSCs and found that inhibition of this enzyme abolishes MSC anti-proliferative effect on T cells, but failed to obtain the same result with neutralizing antibodies to TGF-b or IDO [68].”
• The secretion profile of mesenchymal stem cells and potential applications in treating human diseases (2022, background): “While IFNγ-induced NO synthesis could diminish T cell proliferation,(180) inhibition of iNOS abolishes the mouse MSCmediated anti-proliferative effect on T cells.(181) Recently, we have found that the SH2 domain-containing phosphatase-1 (SHP1) negatively modulates the iNOS expression in MSCs.”
• Mesenchymal stem cells and immunomodulation: current status and future prospects (2016, background): “Extensive data show that the proinflammatory cytokine interferon-γ (IFN-γ), alone or in combination with tumor necrosis factor-α (TNF-α), IL-1α or IL-1β, induces MSCs to secrete various enzymes and soluble factors such as cyclooxygenase 2 (COX-2), PGE2 and IDO that mediate immunosuppressive activity”
• Immunomodulation by Mesenchymal Stem Cells (MSCs): Mechanisms of Action of Living, Apoptotic, and Dead MSCs (2019, background): “There is evidence that the inhibitory effect of MSCs on NK cells involves MSC-secreted prostaglandin E2 (PGE2), IDO, TGF-β1, IL-6 and nitric oxide (NO) (10, 33, 76) (Figure 1A).”
• Immunobiology of mesenchymal stem cells (2013, background): “activity was abolished in MSCs by either chemical inhibition or genetic ablation, the therapeutic effects disappeared.(46,61,62) Meanwhile, iNOS-deficient MSCs also showed less therapeutic effects on autoimmune arthritis in mouse.”
• Mechanisms of mesenchymal stem/stromal cell function (2016, background): “Nitric oxide [45], galectin-1 and semaphorin-3A [46] have also been implicated as MSC-derived modulators of T-cell proliferation, but it is noteworthy to add that nitric oxide has only been shown to function as an MSC modulator in the murine system.”
• Mesenchymal stem cells: mechanisms of inflammation. (2011, background): “MSCs then produce NO, which inhibits Stat-5 phosphorylation, thereby leading to cell-cycle arrest (and thus halting T cell proliferation) (67).”