Mesenchymal stem cells and immunomodulation: current status and future prospects

By F. Gao, S. Chiu, Dal A. L. Motan, Z. Zhang, L. Chen, Hongda Ji, H. Tse, Qinf-Ling Fu, Q. Lian. Cell Death and Disease, 2016

1,007 citations recorded by the source corpus.

The unique immunomodulatory properties of mesenchymal stem cells (MSCs) make them an invaluable cell type for the repair of tissue/ organ damage caused by chronic inflammation or autoimmune disorders. Although they hold great promise in the treatment of immune disorders such as graft versus host disease (GvHD) and allergic disorders, there remain many challenges to overcome before their widespread clinical application. An understanding of the biological properties of MSCs will clarify the mechanisms of MSC-based transplantation for immunomodulation. In this review, we summarize the preclinical and clinical studies of MSCs from different adult tissues, discuss the current hurdles to their use and propose the future development of pluripotent stem cell-derived MSCs as an approach to immunomodulation therapy.

Subfields: Genetics, Surgery, Urology

View Paper: https://www.semanticscholar.org/paper/81f3ece1745cf3e5140fee1f9efd0edaa3f073a1

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1. Jianxun Ding
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3. Yu Han
4. Xue-zhou Li
5. F. Chang

Citations in the corpus

• Mesenchymal Stem Cells for Regenerative Medicine (2019, background): “Their immunological properties, including anti-inflammatory, immunoregulatory, and immunosuppressive capacities, contribute to their potential role as immune tolerant agents [7,8].”