A serine protease, HtrA2, is released from the mitochondria and interacts with XIAP, inducing cell death.

By Yasuyuki Suzuki, Y. Imai, H. Nakayama, Kazuko Takahashi, K. Takio, R. Takahashi. Molecules and Cells, 2001

1,182 citations recorded by the source corpus.

Subfields: Epidemiology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/7773f0edf502565006d52d5994c46298d73e09c3

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Citations in the corpus

Extrinsic versus intrinsic apoptosis pathways in anticancer chemotherapy (2006, background): “This maturation step exposes the IAP-binding motif (IBM) at the N-terminus of Smac/ DIABLO (Du et al., 2000) (Table 1).”
Programmed Cell Death in Animal Development and Disease (2011, neutral): “Mammalian IAP antagonists containing an IBM have also been discovered, including Smac/Diablo and HtrA2/Omi (Verhagen et al., 2000; Suzuki et al., 2001).”
The role of mitochondrial factors in apoptosis: a Russian roulette with more than one bullet (2002, methodology): “The catalytic domain is essential for this cytotoxic activity.(17) ± 20 In addition to its amino-terminal mitochondrial presequence and its catalytic domain, Omi/HtrA2 also has a carboxyterminal PDZ domain.”
Toxic proteins released from mitochondria in cell death (2004, background): “Processing of this second leader, which occurs in a subpopulation of the HtrA2/ OMI pool, exposes an IBM and generates mature 35 kDa HtrA2/OMI (Suzuki et al., 2001a; Hegde et al., 2002; Martins et al., 2002; van Loo et al., 2002b; Verhagen et al., 2002).”
`The stress of dying': the role of heat shock proteins in the regulation of apoptosis (2004, background): “These include cytochrome c (Kluck et al., 1997; Yang et al., 1997a), Smac/Diablo (Du et al., 2000; Verhagen et al., 2000), AIF (Susin et al., 1999), EndoG (Li et al., 2001) and HtrA2/Omi (Suzuki et al., 2001).”
Apoptosis A Link between Cancer Genetics and Chemotherapy (2002, background): “…HtRA2, and cyto- chrome c. Cytochrome c functions with Apaf-1 to induce activation of caspase-9, thereby initiating the apoptoticDisabling Apoptosis: An Important Process caspase cascade, while Smac/DIABLO and HtrA2 bindin Tumor Formation to and antagonize IAPs (Wang, 2001; Suzuki et al., 2001).”