Unique CD14 intestinal macrophages contribute to the pathogenesis of Crohn disease via IL-23/IFN-gamma axis.

By N. Kamada, T. Hisamatsu, S. Okamoto, H. Chinen, Taku Kobayashi, Toshiro Sato, A. Sakuraba, M. Kitazume, A. Sugita, K. Koganei and 2 more. Journal of Clinical Investigation, 2008

694 citations recorded by the source corpus.

Subfields: Genetics, Immunology

View Paper: https://www.semanticscholar.org/paper/2243937bc3e938b8c62eacfe55d38ee7a2e6c5bd

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In Genetics

1. P. Murray
2. Eric E. Schadt
3. Judy H. Cho
4. Steffen Jung
5. Q. Guan
6. TA Wynn

In Immunology

1. Steffen Jung
2. C. Varol
3. P. Murray
4. TA Wynn
5. Miriam Merad
6. M. Mack
7. Judy H. Cho
8. K. Murphy

Citations in the corpus

• Ly6C hi monocytes in the inflamed colon give rise to proinflammatory effector cells and migratory antigen-presenting cells. (2012, methodology): “More recent extensive flowcytometry analysis has provided a more detailed characterization of this population as TREM-1, CX3CR1 , DC-SIGN, and TLR-2 cells and further demonstrated their ability to secrete proinflammatory cytokines like IL-23 and IL-6 in bothCDandUCpatients (Kamada et al., 2008; Sche”
• Single-Cell Analysis of Crohn’s Disease Lesions Identifies a Pathogenic Cellular Module Associated with Resistance to Anti-TNF Therapy (2019, background): “Cytokine-chemokine expression profiles were dominated by CXCL13 in T follicular helper-like (TFH-like) cells and by IL-10 in regulatory T cells (Tregs), which also expressed low levels of IL-17A, as observed previously in iCD lesions (Hovhannisyan et al., 2011).”
• A Comprehensive Review and Update on the Pathogenesis of Inflammatory Bowel Disease (2019, background): “In addition, aberrant CD14-expressing macrophages isolated from the mucosa of IBD patients produce high levels of IL-12 and IL-23 in vitro under the microbial stimulation [104].”
• Protective and pathogenic functions of macrophage subsets (2011, background): “Similarly, in patients with Crohn's disease, researchers identified a population of CD14 + macrophages that are distinct from the normal intestinal macrophage pool and produce large amounts of pro-inflammatory cytokines, including IL-23 and TN”