The relationship between shear stress and flow‐mediated dilatation: implications for the assessment of endothelial function

By K. Pyke, M. Tschakovsky. Journal of Physiology, 2005

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Expert consensus and evidence-based recommendations for the assessment of flow-mediated dilation in humans. (2019, positive): “48,49,98,99 This fits with landmark studies 100,101 demonstrating the importance of shear stress in mediating endothelium-dependent dilation.”
Assessment of flow-mediated dilation in humans: a methodological and physiological guideline. (2011, methodology): “Whereas a strong relation between the “dose” of shear rate and the FMD is observed within young subjects (97, 99, 100), a relatively weak relation has been found between young healthy subjects (114), with no relation reported in other groups (113) (Figs.”
The Impact of High-Intensity Interval Training Versus Moderate-Intensity Continuous Training on Vascular Function: a Systematic Review and Meta-Analysis (2015, methodology): “It should be noted that most participants included in this review were also receiving medications (Table 3) that are known to improve vascular function [40].”