Toll‐like receptor expression in murine DC subsets: lack of TLR7 expression by CD8α+ DC correlates with unresponsiveness to imidazoquinolines

By A. Edwards, S. Diebold, E. Slack, H. Tomizawa, H. Hemmi, T. Kaisho, Shizuo Akira, C. Reis e Sousa. European Journal of Immunology, 2003

633 citations recorded by the source corpus.

Subfields: Immunology

View Paper: https://www.semanticscholar.org/paper/7651b5ed714cac5c4bab0bce9263840edda5531f

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In Immunology

1. Shizuo Akira
2. R. Medzhitov
3. Taro Kawai
4. T. Kaisho
5. R. Flavell
6. J. Tschopp
7. C. Reis e Sousa
8. R. Spörri

Citations in the corpus

• Toll-like receptor function and signaling. (2006, background): “Second, TLR7 expression is very low in cells with high phagocytic activity.(30) Third, the host possesses certain DNA sequences that can inhibit TLR9 signaling, for example in the telomere.”
• Notch–RBP-J signaling controls the homeostasis of CD8− dendritic cells in the spleen (2007, background): “In this in vivo assay, the frequency of IL-12+ DCs was decreased in CKO spleens after challenge with the TLR4 agonist LPS and especially with the TLR7 agonist imiquimod, which preferentially activates CD8− DCs (24, 25).”
• Inflammatory signals in dendritic cell activation and the induction of adaptive immunity (2009, background): “Although some reports suggest that indirectly activated DCs or DCs exposed to TNF-a in vitro can trigger CTL responses in vivo (51), we have found that indirectly 238 2009 The Authors • Journal compilation 2009 Blackwell Munksgaard • Immunological Reviews 227/2009 activated DCs prime CD8+ T cells th”
• Quantitative proteomics reveals subset-specific viral recognition in dendritic cells. (2010, background): “Subsetspecific proteins were detected and validated, including CD97, which was not classified as differentially expressed by microarray studies (Dudziak et al., 2007; Edwards et al., 2003a).”
• Viral infection switches non-plasmacytoid dendritic cells into high interferon producers (2003, methodology): “PDC and conventional CD11c high dendritic cells were purified from splenocyte suspensions as describe”