Tbr1 regulates differentiation of the preplate and layer 6.
By R. Hevner, Limin Shi, Nicholas J. Justice, Y. Hsueh, M. Sheng, S. Smiga, A. Bulfone, A. Goffinet, A. Campagnoni, John L. R. Rubenstein. Neuron, 2001
864 citations recorded by the source corpus.
Subfields: Developmental Neuroscience, Genetics
View Paper: https://www.semanticscholar.org/paper/761be16cdf5162435a44d58567587a9e4a28b525
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Citations in the corpus
- Reconstruction and Simulation of Neocortical Microcircuitry. (2015, background): “Although L6 horizontal and sub-plate pyramidal cells (L6_HPC and L6_SPC) were present in the dataset and have also been reported in the literature (Ghosh and Shatz, 1993; Hevner et al., 2001), the quality of the stains was not sufficient for reliable reconstruction.”
- Neuronal subtype specification in the cerebral cortex (2007, background): “Like Brn1 and Brn2 , Tbr1 is expressed by multiple types of cortical neurons, and its absence has a broad impact on projection neuron differentiatio”
- Pax6, Tbr2, and Tbr1 Are Expressed Sequentially by Radial Glia, Intermediate Progenitor Cells, and Postmitotic Neurons in Developing Neocortex (2005, methodology): “We further demonstrate that Pax6 is substantially downregulated in most Tbr2 ϩ cells, and that, in turn, Tbr2 is reduced to undetectable levels in postmitotic projection neurons, which instead express Tbr1, another T-domain TF (Bulfone et al., 1995; Hevner et al., 2001).”
- Self-organized formation of polarized cortical tissues from ESCs and its active manipulation by extrinsic signals. (2008, background): “Tbr2 is a marker for the progenitors and precursors of late/upper CP neurons (Englund et al., 2005; Hevner et al., 2001 ).”
- Satb2 regulates callosal projection neuron identity in the developing cerebral cortex. (2008, neutral): “Satb2 mutants showed normal expression of Tbr1 (Figures 5A and 5B), which regulates the formation of corticothalamic projections from layer 6 (Hevner et al., 2001, 2002).”