Exosomes from marrow stromal cells expressing miR-146b inhibit glioma growth
By M. Katakowski, Benjamin Buller, Xuguang Zheng, Yong Lu, T. Rogers, O. Osobamiro, Wayne Shu, F. Jiang, Michael Chopp. Cancer Letters, 2013
684 citations recorded by the source corpus.
Exosomes are 30–150 nm vesicles secreted by a wide range of mammalian cells that can contain microRNA (miRNA). To test if marrow stromal cell (MSC) exosomes could be used as a vehicle for delivery of anti-tumor miRNAs, we transfected MSCs with a miR-146b expression plasmid, and harvested exosomes released by the MSCs. Intra-tumor injection of exosomes derived from miR-146-expressing MSCs significantly reduced glioma xenograft growth in a rat model of primary brain tumor.
Subfields: Cancer Research, Molecular Biology
View Paper: https://www.semanticscholar.org/paper/20164756ad0a8d00c929cfe451bd0a4b1488750e
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Citations in the corpus
- Exosomes: vehicles of intercellular signaling, biomarkers, and vectors of cell therapy. (2015, background): “Also, MSC-derived exosomes that express miR-146b inhibited glioma growth (105).”
- Exosomes derived from miR-122-modified adipose tissue-derived MSCs increase chemosensitivity of hepatocellular carcinoma (2015, background): “Furthermore, exosomes can be manufactured in culture by incorporating therapeutic miRNAs into exosomeproducing cells, thereby possibly enabling personalized treatment [16].”
- Review of the Isolation, Characterization, Biological Function, and Multifarious Therapeutic Approaches of Exosomes (2019, background): “Similarly, marrow stromal cell-derived, miR-146b-enriched exosomes are able to silence EGFR and inhibit the proliferation of tumor cells in a rat model of glioma [280].”