DNA damage primes the type I interferon system via the cytosolic DNA sensor STING to promote anti-microbial innate immunity.

By Anetta Härtlova, Saskia F. Erttmann, Faizal A. M. Raffi, Anja M. Schmalz, U. Resch, Sharath Anugula, S. Lienenklaus, L. Nilsson, A. Kröger, J. Nilsson and 3 more. Immunity, 2015

654 citations recorded by the source corpus.

Subfields: Immunology, Infectious Diseases

View Paper: https://www.semanticscholar.org/paper/567c7af6fb192f4de57b55efd18c6c6c0b185832

How researchers see this paper

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In Immunology

1. Zhijian J. Chen
2. Tuo Li
3. G. Barber
4. Aviv Regev
5. Martin Hemberg
6. R. Ransohoff
7. Shizuo Akira
8. A. Ablasser

In Infectious Diseases

1. Tuo Li
2. G. Barber
3. Zhijian J. Chen

Citations in the corpus

• Temporal Tracking of Microglia Activation in Neurodegeneration at Single-Cell Resolution (2017, background): “It is well established that DNA damage can lead to the induction of type 1 interferons (Härtlova et al., 2015).”
• The cGAS–cGAMP–STING pathway connects DNA damage to inflammation, senescence, and cancer (2018, background): “…other cytokines (Fenech and Morley, 1986; Schlegel et al., 1986; Coppé et al., 2008; Rodier et al., 2009; Brzostek-Racine et al., 2011; Fenech et al., 2011; Kondo et al., 2013; Ahn et al., 2014b; Lan et al., 2014; Härtlova et al., 2015; Xia et al., 2016a; Harding et al., 2017; Luthra et al., 2017).”
• STING: infection, inflammation and cancer (2015, positive): “The importance of STING in generating cytokines in response to DNA damage has been further emphasized in cells with defects in their DNA repair machinery 92, 93 .”
• cGAS surveillance of micronuclei links genome instability to innate immunity (2017, positive): “ISG transcript induction was also observed (Extended data Fig 1g) at levels comparable to previous studies of genotoxic damage2,4.”