Retrospective birth dating of cells in humans.

By K. Spalding, R. Bhardwaj, B. Buchholz, H. Druid, J. Frisén. 2005

613 citations recorded by the source corpus.

Subfields: Developmental Neuroscience, Molecular Biology

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Developmental Neuroscience

1. R. Hen
2. Hongjun Song
3. Guo-li Ming
4. Fred H. Gage
5. B. R. Miller
6. J. Frisén
7. K. Spalding
8. O. Bergmann

In Molecular Biology

1. R. Hen
2. P. Zammit
3. Hongjun Song
4. Guo-li Ming
5. B. R. Miller
6. L. Diaz
7. T. Partridge
8. J. Frisén

Citations in the corpus

• Adult Neurogenesis in the Mammalian Brain: Significant Answers and Significant Questions (2011, background): “In both insulin-deficient rats and insulin-resistant mice, diabetes impairs cell proliferation in the adult SGZ through a glucocorticoid-mediated mechanism (Stranahan et al., 2008).”
• Dynamics of hippocampal neurogenesis in adult humans (2013, neutral): “When we eat plants, or animals that live off plants, we take up 14 C, meaning that atmospheric 14 C levels are mirrored in the human body at all times (Harkness, 1972; Libby et al., 1964; Spalding et al., 2005b).”
• Hippocampal neurogenesis: regulation by stress and antidepressants. (2006, methodology): “A clever approach using changes in atmospheric carbon 14 concentrations following atomic bomb testing in the 1950s was recently used to demonstrate that human cortical cells do not turn over with time (Spalding et al 2005), but the hippocampus was not examined in the study.”
• Neurogenesis in the striatum of the adult human brain. (2014, neutral): “DNA repair is thought to be very limited in postmitotic cells, and well below the detection limit of carbon dating (Spalding et al., 2005).”
• Dynamics of Cell Generation and Turnover in the Human Heart. (2015, background): “Another strategy for birth dating cells relies on analyzing incorporation of nuclear bomb test-derived (14)C into genomic DNA (Spalding et al., 2005), and this approach indicated a much lower turnover rate in humans, with the majority of cardiomyocytes never being exchanged even during a long life (”
• Mechanisms and functional implications of adult neurogenesis. (2008, neutral): “…finding is supported by several independent approaches, including the BrdU method and a cell birth-dating method based on the level of 14C in the genomic DNA of individual cortical neurons (Eriksson et al., 1998; Cell 132, 645–660, February 22, 2008 ª2008 Elsevier Inc. 655 Spalding et al., 2005).”
• TERT promoter mutations occur frequently in gliomas and a subset of tumors derived from cells with low rates of self-renewal (2013, background): “Normal hepatocytes also do not turnover often (39), and glial cells are thought to have limited capacity for self-renewal (40).”
• The current state of the neurogenic theory of depression and anxiety. (2015, methodology): “To measure AHN directly, one must birthdate neurons, for instance using radiocarbon birthdating [24].”
• Glucose restriction inhibits skeletal myoblast differentiation by activating SIRT1 through AMPK-mediated regulation of Nampt. (2008, background): “Since the contribution of satellite cells to physiological muscle fiber growth and maintenance in the adult animal is small (Spalding et al., 2005), it is likely that AMPK and SIRT1 may be differently activated and mediate distinct outcomes in cultured muscle cells exposed to low glucose and in musc”
• Adipocyte Turnover: Relevance to Human Adipose Tissue Morphology (2009, methodology): “The renewal of adipocytes in vivo was estimated using our recently developed method to measure (14)C in DNA (18,24) and set it in relation to the atmospheric radioactivity.”