Tumour suppressor RNF43 is a stem-cell E3 ligase that induces endocytosis of Wnt receptors

By Bonil Koo, M. Spit, Ingrid Jordens, T. Low, D. Stange, M. Wetering, J. V. Es, S. Mohammed, Albert J. R. Heck, M. Maurice and 1 more. Nature, 2012

941 citations recorded by the source corpus.

Subfields: Molecular Biology, Oncology

View Paper: https://www.semanticscholar.org/paper/755df8ef22ff15bdf56aa8a5a29f3b73f7c91e52

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Molecular Biology

1. Hans Clevers
2. R. Nusse
3. S. Angers
4. Z. Steinhart
5. Alexander van Oudenaarden
6. K. Loh
7. R. Vries
8. Yanqin Zuo

In Oncology

1. Hans Clevers
2. R. Nusse
3. S. Angers
4. Z. Steinhart
5. K. Loh
6. Alexander van Oudenaarden
7. Bonil Koo
8. Inha Heo

Citations in the corpus

• Wnt/β-catenin signaling in cancers and targeted therapies (2021, background): “Znrf3 and Rnf43 were not essential in the intestine but dysregulation of Znrf3/Rnf43 was important for the growth of CRC.(26,27,123) Mutations of Rnf43, resulting in E3 ubiquitin ligases function loss, promoted CRC development and poor prognosis.”
• An integral program for tissue renewal and regeneration: Wnt signaling and stem cell control (2014, background): “R-spondins, acting through Lgr family receptors (11–13), inhibit the transmembrane E3 ubiquitin ligases Rnf43/Znrf3 that ordinarily ubiquitinate and thus degrade Frizzled receptors (14, 15).”
• Prospective derivation of a Living Organoid Biobank of colorectal cancer patients (2015, background): “…et al., 2014; Ryland et al., 2013; Wang et al., 2014), and RNF43 mutations have been observed in 936 Cell 161, 933–945, May 7, 2015 ª2015 Elsevier Inc. CRC (Giannakis et al., 2014; Ivanov et al., 2007; Koo et al., 2012) We found APC alterations in all but four of the organoids (P11, P19a/b, P28).”
• Wnt signaling in development and tissue homeostasis (2018, background): “Rnf43 and Znrf3 are recently characterized Wnt-β -catenin target genes that encode transmembrane E3-ubiquitin-ligases (Hao et al., 2012; Koo et al., 2012) involved in ubiquitin-dependent Frizzled endocytosis and proteasomal degradation, thereby reducing receptor levels at the plasma membrane.”
• Inactivating mutations of RNF43 confer Wnt dependency in pancreatic ductal adenocarcinoma (2013, background): “Intestinal-specific deletion of both Znrf3 and Rnf43 induces hyperproliferation of intestinal crypts and formation of intestinal adenoma in mice (14).”